Clinical multi-center study on the treatment of sudden sensorineural hearing loss accompanied with feeling of ear fullness / 中华耳鼻咽喉头颈外科杂志

<p><b>OBJECTIVE</b>To investigate the therapeutic effect of drug treatment for patients with sudden sensorineural hearing loss (SSNHL) accompanied with feeling of ear fullness (FEF).</p><p><b>METHODS</b>A prospective clinical multicenter research was carried out from August 2007 to October 2011. SSNHL patients aged between 18 to 65 years old and accepted no medication were recruited, with a duration less than two weeks. The patients were divided into four types according to the hearing curve: type A was acute SSNHL in low tone frequencies, type B was acute SSNHL in high tone frequencies, type C was acute SSNHL in all frequencies, and type D was total deafness. Each type was subdivided into two groups by the accompaniment of SEF or not. And each type had four different treatment programs, based on the unified designed randomized table. All patients were followed up for four weeks from the initial examination.</p><p><b>RESULTS</b>A total of 1 024 cases with single side SSNHL were recruited in the study from 33 hospitals in China, including 565 cases accompanied with FEF (55.18%), and 459 cases without FEF (44.82%). By classification of audiogram, 205 cases were type A (20.20%), of whom 122 were accompanied with FEF (59.51%); 141 cases belonged to type B (13.77%), of whom 74 were accompanied with FEF (52.48%); 402 cases were type C (39.25%), of whom 229 were accompanied with FEF (56.97%); and 276 cases were classified as type D (26.95%), of whom 140 were accompanied with FEF (50.72%). No significant difference was observed in total effective rate between the SSNHL patients accompanied with FEF or not in four acoustic types (P > 0.05). Among four acoustic types, the clinical cure rate of patients accompanied with FEF in type A was 93.44%, ranking the first; followed by 84.28% for type C; 75.71% for type D; and 70.27% for type B, respectively.</p><p><b>CONCLUSIONS</b>The therapeutic effect for patients accompanied with FEF in type A is satisfactory. The presence of FEF do not impact the therapeutic effect for SSNHL patients.</p>

Correlation analysis of bacterial biofilm formation and bacterial culture in chronic otitis media / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To study the correlation between the bacterial biofilm formation and bacterial culture in chronic otitis media.@*METHOD@#As a prospective reserch, we used scanning electron microscopy to examinate patients samples which collected from 32 cases of patients with chronic suppurative otitis media and middle ear cholesteatoma in the operations, and performed the middle ear secretions bacterial culture. According to the different types of chronic otitis media group, we analysised the relationship between chronic otitis media bacterial biofilm formation and the bacterial culture results.@*RESULT@#Chronic suppurative otitis media (activity) and middle ear cholesteatoma bacterial biofilm formation rate were 87.5%, 81.3%, chi-square (P > 0.05). Compared bacterial biofilm results with the results of bacterial cultured in chronic otitis media, sensitivity was 70.37%, specificity was 60.00%, the misdiagnosis rate was 40.00%, the missed diagnosis was 29.63%, positive predictive value was 90. 46%, negative predictive value was 27.27%, accuracy was 68.75%. Youden index was 30. 37%, and Pearson correlation coefficient was 0.232 (P > 0.05).@*CONCLUSION@#Chronic suppurative otitis media (activity) and middle ear cholesteatoma bacteria had a higher biofilm formation rate. The routine bacterial culture results can't reflecte bacterial biofilm formation in chronic otitis media. We need to explore more reliable experimental methods to accurately reveal the infection status of chronic otitis media.

The Analysis of the Main Pathogenic Bacteria and Drug Sensitivity in Patients with Chronic Suppurative Otitis Media and Patients with Middle Ear Cholesteatoma in Xinjiang / 听力学及言语疾病杂志

Objective To study the main pathogenic bacteria and drug sensitivity in patients with chronic sup-purative otitis media and patients with middle ear cholesteatoma in Xinjiang ,and to provide evidence for reasonable u-sing antibiotics for the two diseases .Methods We performed a retrospective analysis of the middle ear secretion bac-terial culture results of 409 patients with chronic suppurative otitis media and middle ear cholesteatoma at our hospi-tal from January 2008 to December 2013 .Results ①There were 361 strains of microbes isolated from 409 patients , and 16 of them were fungi ,and 245 were bacteria .There was a statistical significance of the pathogen detection rate about G+ and G- bacteria between chronic suppurative otitis media and middle ear cholesteatoma (χ2 =12 .216 ,P=0 .000) .②Staphylococcus aureus(in 78 of 254 ears ,30 .7% ) ,pseudomonas aeruginosa(in 46 of 254 ears ,18 .1% ) , coagulase-negative staphylococcus(in 42 of 254 ears ,16 .5% ) ,and proteus mirabilis(in 20 of 254 ears ,7 .87% ) were the most frequently insolated pathogens in chronic suppurative otitis media ,while staphylococcus aureus(in 26 of 107 ears ,24 .30% ) ,pseudomonas aeruginosa(in 17 of 107 ears ,15 .9% ) ,coagulase-negative staphylococcus (in 16 of 107 ears ,15 .0% ) ,and proteus mirabilis(in 14 of 107 ears ,13 .1% ) were the most frequently insolated patho-gens in middle ear cholesteatoma .③Staphylococcus aureus and coagulase -negative staphylococcus were all sensi-tive to quinoline nupu ting /dalfopristin ,teicoplanin ,vancomycin ,and moxifloxacin .The sensitivity of coagulase -negative staphylococcus to gentamicin ,trimethoprim -sulfamethoxazole ,and erythromycin in the middle ear chol-esteatoma were higher than those of in chronic suppurative otitis media .The sensitivity of pseudomonas aeruginosa to ceftazidime ,and imipenem were lower in the middle ear cholesteatoma .The drug sensitivity of pseudomonas aeruginosa ,proteus to trimethoprim/sulfamethoxazole and cefazolin was higher in middle ear cholesteatoma .Conclu-sion There are differences between chronic suppurative otitis media (active) and middle ear cholesteatoma about G+ ,G- bacteria detection rate .Staphylococcus aureus ,coagulase-negative staphylococcus ,pseudomonas aerugi-nosa ,and proteus mirabilis are the main pathogenic bacteria in these two chronic otitis media .There is a difference of some commonly used antimicrobial sensitivity in these two kinds of otitis media ,which is more obvious in pseudo-monas aeruginosa and proteus mirabilis .

Expanding Translabyrinthine Approach Microsurgery Resection of Large Acoustic Neuroma / 听力学及言语疾病杂志

Objective To explore the microsurgery technique and outcome of expanding translabyrinthine ap-proach resection large acoustic neuroma .Methods We have retrospectively studied clinical data and follow -up re-sults of 4 patients of large acoustic neuroma (≥5 cm ,the largest was 8 cm ;3 cases with servere sensorineualt hear-ing loss ,1 case with high frequenoy hearing loss ;1 case with blindness) in our hospital between January 2013 and April 2013 .All patients received expanding translabyrinthine approach microsurgery to resecting the tumors .Post-operative follow -up was 6~10 months .Results The large acoustic neuroma of 4 cases were totally removed via MRI reexamination after operation .Facial nerve in 3 cases were dissection retained ,and 1 case received facial nerve anastomosis .Six months after operatin ,one patient’s facial nerve function recovered from level Ⅲ to level Ⅱ ,the patient underwent facial nerve anastomosis with facial paralysis level Ⅵ recovered to level Ⅳ ,and the vision of pa-tient with blindness completely recovered to normal .Conclusion The expanding translabyrinthine approach can to-tally resect large acoustic neuroma and preserve facial nerve function .

Clinical analysis of 20 patients with primary non-Hodgkin's lymphoma of nasal cavity and nasopharynx / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To evaluate the treatment policy for non-Hodgkin's lymphoma of the nasal cavity and nasopharynx.@*METHOD@#Twenty patients with pathologically confirmed non-Hodgkin's lymphoma of nasal cavity and nasopharynx,treated from Jan. 2006 to Oct. 2010, were retrospectively reviewed.@*RESULT@#The 3-year overall survival and complete response rates for all patients were 78% and 47% respectively. The 3-year overall survival rates for patients treated with chemotherapy and patients treated with chemotherapy plus radiotherapy were 75% and 82% respectively. The estimates of complete response for patients receiving chemotherapy alone and for patients receiving chemotherapy plus radiotherapy were 37% and 55%, respectively. The 3-year overall survival rates for patients who achieved complete response and patients who did not were 89% and 70%, respectively. The 3-year overall survival rates for patients in stage IE and stage II E were 92% and 57%, respectively.@*CONCLUSION@#There was no significant difference between chemotherapy alone and chemotherapy plus radiotherapy for the treatment of non-Hodgkin's lymphoma of the nasal cavity and nasopharynx. The 3-year overall survival rate for patients in stage IE was much higher than in stage II E. Early treatment is very important to improve the survival rate of the patients.

Efficacy of partial laryngectomy for glottic carcinoma / 中国耳鼻咽喉头颈外科

OBJECTIVE To evaluate the efficacy and the recovery of laryngeal functions of various kinds of partial laryngectomy for glottic carcinoma.METHODS The clinical data of 75 patients with glottic carcinoma who underwent partial laryngectomy in our department from Jan. 1997 to Dec. 2006 were retrospectively analyzed. Seventy one cases were male and 4 cases were female. There were 6 kinds of surgical methods for those patients. CO2 laser assisted vocal cordectomy was operated on in 12 cases,vocal cordectomy through laryngofissure in 18 cases,vertical partial laryngectomy in 33 cases,frontal partial laryngectomy in 5 cases,extended vertical partial laryngectomy in 4 cases,and CHEP in 2 cases. RESULTS The overall 3 and 5 year survival rates of the patients were 97.3% and 94.6% respectively. The 3 and 5 year survival rates in 48 cases with stage T1/T2 were 97.9% and 97.9% and those in 27 cases with stage T3/T4 were 92.5% and 85.1%. All of the patients restored the phonation and swallowing function. The decannulation rate was 92.1%(58/63). The decannulation rate of the patients within one month after operation was 85.2% CONCLUSION Partial laryngectomy is the first choice of the radical treatments for glottic carcinoma. Strict indications,correct procedure and surgical repair methods are the keys to ensure the efficacy and preservation of laryngeal function.

Treatment of compensatory turbinate hypertrophy with radiofrequency ablation / 中国耳鼻咽喉头颈外科

OBJECTIVE To evaluate the efficacy of radiofrequency ablation on treatment of compensatory turbinate hypertrophy.METHODS A total of 105 patients enrolled in the study.Fifty cases only accepted the relocation of inferior turbinate and 55 cases accepted radiofrequency ablation of inferior turbinate during nasal septum deviation surgery under nasal endoscope.The preoperative and postoperative nasal obstructions were assessed with visual analogue scale(VAS).RESULTS The outcome of 105 patients undergoing different operation for below 1 months,3～6 months,above 6 months after operation were recorded.The results of treatment group were better than that of the control group.CONCLUSION The use of radiofrequency ablation for the treatment of compensatory turbinate hypertrophy is an effective method for reducing symptoms of nasal obstruction after relocation of inferior turbinate.

Intelligentized control system of microwave curer / 医疗卫生装备

This paper introduces the application of P80C552, a microprocessor with ADC, to microwave curer. The principle and functions of the curer presented, the hardware and software designs of its intelligentized control system are described in detail. The designs, making the curer reliable and stable, prove practical.