Risk factors of rehospitalization in psychiatric inpatients within one year after discharge / 四川精神卫生

ObjectiveTo explore the risk factors of rehospitalization of psychiatric inpatients within one year after discharge， so as to provide references for clinical evaluation and intervention. MethodsData of patients hospitalized in the Brain Hospital Affiliated to Guangzhou Medical University from 2013 to 2017 was collected through the electronic medical record system. Survival analysis was carried out to screen the risk factors for patient readmission. Cox risk regression and survival curve analysis were also performed， meantime， multiple linear regression was used to analyze the influencing factors of the time intervals between hospital discharge and subsequent readmission within one year. ResultsAmong the 22 807 hospitalized patients， 4 602 cases （20.2%） were readmitted within one year after discharge. Age， payment methods， disease diagnosis， number of hospitalizations and hospitalization days were risk factors for readmission （P<0.01）. The readmission rates of patients aged 21~30， 31~40， 41~50 and 51~60 were 0.706， 0.631， 0.610 and 0.693 times higher than those aged ≤20， respectively. The probability of readmission of patients with twice， three times and four times of hospitalization before was 3.015， 2.824 and 4.271 times higher than those with one time of hospitalization， respectively. The readmission rate of patients hospitalized for 21~40 days and above 101 days were 1.142 and 1.181 times higher than those hospitalized for less than 20 days， respectively. Age， hospitalization days and number of hospitalizations were the influencing factors of readmission within one year after discharge， and patients with older age had longer intervals between discharge and subsequent readmission （B=0.017， P<0.01）. The time intervals between discharge and subsequent readmission were significantly longer among patients who had been hospitalized for 61~80 days than among patients who had been hospitalized for less than 20 days （B=1.226， P<0.01）. Compared with patients with one time of hospitalization， the time intervals was significantly shorter among patients with twice of hospitalization （B=-1.386， P<0.01）. ConclusionPatients aged below 20 years old and those with two， four or more times of hospitalization before have a high rate of readmission within one year after discharge， and the readmission time may be earlier among patients with two times of hospitalization， and relatively later among patients who had been hospitalized for 61~80 days.

Rapid Identification and Quality Analysis of Olibanum by TGA-DTA Thermal Analysis / 世界科学技术-中医药现代化

This study was aimed to quickly identify Chinese medicine Olibanum.Thermal analysis method was used on the quality analysis of Chinese materia medica (CMM).A total of 25 batches of Olibanum on the market were collected.This study examined three important factors of temperature range,heating rate,powder mesh on the TGA and DTA thermal analysis experiments.And a method of rapid authentication of medicinal materials using TGA and DTA feature maps was built.Methods of the first-order points,connection on thermogravimetric analysis and heat enthalpy calculation were adopted in the quantitative analysis of Olibanum.The results showed that the best condition of TGA and DTA experiment on Olibanum was confirmed.The temperature range is 50-750℃.The heating rate is 20℃· min-1.The powder mesh is 100 mesh.Under these conditions,good quality goods of Olibanum,counterfeit Olibanum and adulterants of Olibanum could be distinguished through the characteristic peak (T1=447 ± 5℃,T2=549 ± 5℃,T3=350 ± 5℃),thermogravimetric analysis (TV-max,△W2+△W3) and thermal enthalpy analysis (△H).It was concluded that the TGA-DTA technology was simple.It was thought to be a rapid,accurate and simple new method for Olibanum identification and quality analysis.

HPLC fingerprint of Venenum Bufonis / 中成药

AIM: To establish HPLC fingerprint of Venenum Bufonis in an attempt to become a standard of quality control. METHODS: The HPLC method was set up using Alltima C_(18)(250 mm?4.6 mm,5 ?m) column with mobile phase of acetonitrile-0.5% potassium dihydrogen phosphate solution of water;UV detection wavelength at 296 nm and column temperature at 30 ℃ with the flow rate of 1.0 mL/min;20 ?L of the injection volume. RESULTS: In this chromatogram condition,10 peaks were identified as the characteristic fingerprints of Venenum Bufonis.All samples showed the content differences among the samples.The retention times for resibufogenin、cinobufagin、bufalin、bufotalin and cinobufotalin in Venenum Bufonis were consistent with each other.The fingerprint showed good similarity up to 93% in samples from different habitats. CONCLUSION: The method is exact、simple and accurate,and can be used for the identification and quality control of Venenum Bufonis.