RESUMO
Anhedonia is the loss of pleasure or lack of reaction to pleasurable stimuli, which is a promising phenotype of depression. In order to explore the potential biological mechanism, the recent ad?vances were summarized from researches focused on depression with anhedonia from neuroanatomy,inflamma?tion and immunology,and molecular genetics. The structural and functional brain imaging showed that the ac?tivity in reward?related brain regions of the depressive disorder with an anhedonia was changed during re?ward?related tasks.In addition,some other genetic studies based on the related neurotransmitter,such as do?pamine, together with the findings from the researches on immunological inflammation, may shed light on finding the potential targets for novel antidepressants,besides the 5?HT.
RESUMO
Objective:To observe the expression of cytokine receptor in neuron and astrocyte of the hippocampus of rats in depression. Methods:The depression model was produced by separation and un-predicted mild stressors. The behavior was measured by open -field test.The rats acceived electric convulsive therapy(ECT) or modified electric convulsive therapy (MECT)treatment. The expression of cytokine receptor in neuron and astrocyte of the hippocampus was observed by the immunofluorescence detection technique. Results:There were significant differences among the stress and ECT group ,the stress and MECT group and the stress and shame-electroshock group in the two test. Conclusion:Both the ECT and the MECT treatment can promote the expression of cytokine receptor in neuron and astrocyte of the hippocampus of rats in depression. The cytokine(CK)may play an important role in the pathophysiological mechanism of depression. And the MECT treatment may be more effective than the ECT treatment.