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Objective To investigate the role of mylin basic protein,S100B and arterial blood gas analysis's levels in early diagnosis of brain injury in premature infant.Methods A total of 95 premature infants treated in our hospital were enrolled in the study.Experimental group was 45 premature infants with brain injury.Control group was 50 premature infants without brain injury were the.All patients were detected with arterial blood gas analysis,MBP and S100B on the 1st day and 7th day after birth.Results The pH,PCO2,BE,lactic acid,MBP and S100B's levels in experimental group were significantly different between the 1st day and 7th day after birth.In the 1st day after birth,compared with the control group,the pH,PCO2,BE,lactic acid,MBP and S100B in the experimental group were obviously high than that of control group.Conclusion On the 1st day after birth,monitoring arterial blood gas analysis,S100B protein and MBP's levels could be useful in early diagnosis of brain injury in preterm infants.
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Objective To investigate the early diagnosis value of arterial blood gas analysis , neuron specific enolase and serum glial fibrillary acidic protein in brain injury of premature infant. Methods In the study, 95 premature infants admitted in our hospital were enrolled. 45 premature infants with brain injury were selected as experimental group. 50 premature infants without brain injury were selected as control group. All patients received arterial blood gas analysis , NSE and GFAP on the 1st day and 7th day after birth. Results There is statistically significant difference between the experimental group and the control group on the 1st day after birth in terms of pCO2, pH, BE and lactic acid (P<0.05). In experimental group, there is statistically significant difference between the 1st day and 7th day after birth in terms of pCO2, pH, BE and lactic acid (P < 0.05). The NSE and GFAP levels had statistically significant difference between the experimental group and the control group on the 1st day and 7th day after birth(P < 0.01); the NSE levels of experimental group had statistically significant difference between the 1st day and 7th day after birth (P < 0.05); The GFAP levels of experimental group had statistically significant difference between the 1st day and 7th day after birth (P < 0.01). Conclusion pCO2, NSE and GFAP levels are correlated with brain damage in premature infants in early stage. This could provide evidence of early diagnosis for brain injury in preterm infants.
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Objective To evaluate the therapeutic effect of Kangbingdu oral liquid in combination with ribavirin aerosol for hand, foot, and mouth disease (HFMD). Methods A total of 135 HFMD children were enrolled and assigned to receive ribavirin aerosol alone (ontrol group, 67 patients) or ribavirin aerosol plus Kangbingdu oral liquid group (treatment group, 68 patients) for 7 days. Therapeutic effect was evaluated as the time to fever resolution, subsidence of skin rash and oral ulcers. All throat swab samples were tested using a fluorescence quantitative RT-PCR assay for panenteroviruses, enterovirus 71(EV71)and Coxsackievirus A16 (CA16). Results The time to fever resolution(2.51±0.42 d vs. 3.92±0.61 d;t=15.621, P<0.01), subsidence of skin rash(4.22±1.34 d vs. 6.33±1.41 d;t=8.914, P<0.01)and oral ulcers(3.01±0.32 d vs. 4.52±1.21 d;t=9.880, P<0.01)in the treatment group were significantly shorter than those in the control group. The healing rate in the treatment group were significantly higher than that in the control group(88.2%vs. 44.8%;χ2=26.761, P<0.01), and total effective rate was no different in treatment and control groups(94.1%vs. 83.6%;χ2=2.801, P=0.094). The rates of conversion from positive to negative for panenteroviruses(90.9% vs. 52.6%;χ2=13.331, P<0.01)and EV71(83.3%vs. 52.4%;χ2=4.307, P=0.038)in the treatment group were significantly higher than those in the control group, and the rate of conversion from positive to negative for CA16 was no different in treatment and control groups(93.3%vs. 81.8%;χ2=0.082, P=0.774). Conclusion Kangbingdu oral liquid in combination with ribavirin aerosol may improve the rate of conversion from positive to negative for enteroviruses, reduced the time to fever resolution, subsidence of skin rash and oral ulcers in HFMD children.