RESUMO
Library is an important department of university,which performs active function on building the harmonious university.By developing new content and manners we have broke through the intrinsic thinking mode in service of library and have made a useful exploration and practice on service innovation,which has effectively promoted the construction and development of the harmonious university.
RESUMO
Objective:To study and evaluate the protecting effect of levofloxacin hydrochloride on systemic infection in mice. Methods :960 mice were used,and divided randomly into 96 groups. Certain amount of E. coli,S. aureus,P. aeruginosa and S. flexneri were administered respectively into the mice and all of them were infected. Immediately after being infected,each group of mice were given different doses of intravenous or oral levofloxacin hydrochloride and of loxacin, in order to determine the protective effect of levofloxacin hydrochloride on the mice infected with these four bacteria. Results: The intravenous injection of ED50 of levofloxacin hydrochloride to the bacteria strains was 0.359mg/kg,5.848mg/kg,22.894mg/kg and 0. 371mg/kg respectively;and ED50through the oral route was 0. 554mg/kg,8. 129mg/kg,28. 895mg/kg and 0. 492mg/kg respectively. Conclusion :The protecting effect through intravenous injection of levofloxacin hydrochloride on systemically infected mice is more superior to that of the oral route,and also better than ofloxacin.