Etiology and epidemiology of chronic cough aged 6-14 years in children / 公共卫生与预防医学

Objective To investigate the incidence and risk factors of chronic cough in children aged 6-14 years. Methods The incidence of chronic cough in children aged 6-14 years in Qinhuangdao city was investigated by questionnaire. Results A total of 4 000 questionnaires were distributed, 3 785 of them were effectively recovered, with the recovery rate of 94.6%. The incidence of chronic cough in children aged 6-14 was 5.1% (194/3 785). The prevalence rates of boys and girls were 5.4% (101/1 859) and 4.8% (93/1 926), respectively, with no significant difference (χ2=0.641，P=0.873). The incidence rate of children in industrial town area 6.7% (64/955) was significantly higher than that in urban area 4.4% (85/1 917) and agricultural town 4.9% (45/913) (χ2=55.082，P=0.000). The risk factors showed that chronic cough was associated with long-term allergen exposure, allergic constitution, asthma, rhinitis, reflux esophagitis and other nasopharynx diseases (χ2=17.833，43.370，194.466，27.773，101.92，11.268，P =0.000). Regression model analysis showed that asthma, rhinitis and allergen long-term exposure were independent risk factors of chronic cough (Wald=15.352，10.174，12.625，12.659，P =0.000). Conclusion The incidence rate of children in industrial town is higher in Qinhuangdao City than those in other urban areas, 6~14 years old children. Asthma, rhinitis and allergen exposure are the main causes of chronic cough.

Antitumor activities of liposoluble components of caulis Marsdeniae tenocissimae and analysis on its chemical constituents / 中国中药杂志

<p><b>OBJECTIVE</b>To study the antitumor activities of the liposoluble components from caulis Marsdenia tenocissimae and analyze its chemical constituents.</p><p><b>METHOD</b>The supercritical fluid extraction was used to extract the liposoluble components from caulis M. tenocissimae. MIT test was applied to study the anticancer effects of liposoluble components on growth inhibition in human liver cancer line HepG-2 cells, and the chemical constituents were analyzed by gas chromatography/mass spectrometry (GC-MS).</p><p><b>RESULT</b>The liposoluble components of caulis M. tenocissimae have obvious growth inhibitory action to HepG-2 cells. Twenty-four compounds were identified and their relative contents were determined.</p><p><b>CONCLUSION</b>The liposoluble components from caulis M. tenocissimae have antitumor activities, and its pharmacological activity is related to its chemical constituents.</p>