RESUMO
Idiopathic oligoasthenospermia （IO） has been increasingly emphasized in the diagnosis and treatment of male infertility. Oxidative stress damage directly affects sperm quality and spermatogenesis， constituting a major causative factor of IO. Firstly， due to its high content of polyunsaturated fatty acids， the sperm plasma membrane is highly sensitive to reactive oxygen species （ROS）， leading to lipid peroxidation accumulation and even inducing ferroptosis. Secondly， deficient downstream key proteins in the base excision repair pathway render sperm unable to repair extensive DNA oxidative damage under oxidative stress. Simultaneously， under oxidative stress， the apoptotic pathway of sperm is cascade-activated， causing rapid loss of motility. ROS further disrupts the hypothalamic-pituitary-gonadal axis， inhibiting testosterone production and ultimately affecting spermatogenesis. Wuzi Yanzongwan，in line with traditional Chinese medicine theory of treating IO through "nourishing kidney essence and harmonizing Yin and Yang"， clinically demonstrates its ability to improve sperm morphology， count， and motility， thereby enhancing male fertility. The research on the pharmacological constituents of Wuzi Yanzongwan primarily involves establishing a characteristic spectrum of Chinese medicine to achieve quality control and exploring the pharmacology of effective components. Studies have found that its main active ingredients consist of flavonoids and phenylpropanoids. Specifically， compounds such as hyperin， acteoside， kaempferol， and schisandrin A are identified as the primary active substances and quality control components. These compounds exhibit strong antioxidant activity and have been partly applied in research related to reproductive endocrine disorders. Tripterygium glycoside is primarily used for modeling of oxidative stress-induced IO. It leads to the accumulation of various lipid peroxides in testicular tissues and concurrently compromises the body's antioxidant capacity. Mechanistic studies have found that Wuzi Yanzongwan can inhibit elevated ROS levels in IO models and enhance the body's antioxidant capacity， thereby ameliorating inflammation， suppressing cell apoptosis， promoting testosterone production， and ultimately alleviating the decline in sperm quality and spermatogenesis caused by oxidative stress.
RESUMO
Objective: To explore the ralationship between common used TCM prescriptions and syndrome elements in acute ischemic stroke and to lay a foundation for further study of the correspondence of the prescription and the syndrome. Methods: We extracted the clinical information of 359 patients (451cases) who were in accordance with the inclusive criteria and were given Wendan Decoction, Xinglou Chengqi Decoction, Zhengan Xifeng Decoction and Tianma Gouteng Decoction, Buyang Hanwu Decoction and Banxia Baizhu Tianma Decoction. We investigated the correlation between six prescriptions and six syndrome elements through comparing the mean value of score of each syndrome element which was corresponding to each prescription. Then we obtained their odds ratio by using the multiple logistic regression. Results: The mean value of wind syndrome, fire syndrome and phlegm syndrome were the top three in the cases who drank Wendan Decoction, Xinglou Chengqi Decoction, Zhengan Xifeng Decoction. The mean values of wind syndrome, phlegm syndrome, syndrome of blood stasis were in the top three in the cases who drank Buyang Huanwu Decoction. By analyzing logistic regression, Wendan Decoction had close correlation with phlegm syndrome, Xinglou Chengqi Decoction had close correlation with phlegm syndrome or fire syndrome, Tianma Gouteng Drink had close correlation with syndrome of hyperactivity of yang due to yin deficiency, Buyang Huanwu Decoction had close correlation with syndrome of qi deficiency or syndrome of blood stasis, Banxia Baizhu Tianma Decoction had close correlation with wind syndrom or phlegm syndrome, and the correlations above were all positive, Zhengan Xifeng Decoction had close correlation with phlegm syndrome or syndrome of qi deficiency, and their correlation was negative. Conclusion: The prescription corresponded with the syndrome element, and it was the key points in clinical practice.