Mechanism of Duhuo Jisheng decoction in treatment of knee osteoarthritis based on network pharmacology / 中国药理学通报

Aim To study the mechanism of Duhuo Jisheng decoction in the treatment of knee osteoarthritis (KOA) by network pharmacology. Methods The active components of Duhuo Jisheng decoction were screened on traditional Chinese medicine systems pharmacology (TCMSP) platform according to research criteria, and the targets of KOA were predicted in GeneCards database. The "TCM-component-target-disease" network was constructed by Cytoscape software. The Venn diagram was built to extract the target of Duhuo Jisheng decoction in the treatment of KOA. The PPI network of Duhuo Jisheng decoction in the treatment of KOA was constructed, and the network feature analysis was made by Network Analyzer. The gene oesthetics (GO) function annotation and Kyoto Encyclopedin of Genes and Genomes (KEGG) signaling pathway enrichment analysis were performed. Results Totally 154 components and 130 potential targets in Duhuo Jisheng decoction and 1878 targets relating to KOA were excavated, and 63 common targets of Duhuo Jisheng decoction-ROA were obtained. The common targets were mainly enriched in 68 biological processes and 117 signaling pathways. Conclusions Duhuo Jisheng decoction may regulate targets, such as IL6, VEGFA, ALB, EGFR, CASP3, MAPK8, MYC, and adjust AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway and apoptosis, so as to inhibit the inflammatory response and adjust apoptosis to treat KOA.

Treatment of Steroid-induced Osteonecrosis of Femoral Head by Porous Tantalum Rod and Gugutou Huaisiyu Capsule / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To observe the curative effect of porous tantalum rod and Gugutou Huaisiyu Capsule (GHC) for steroid-induced osteonecrosis of femoral head (SONFH).</p><p><b>METHODS</b>A total 60 hips of 50 SONFH patients were randomly assigned to the treatment group and the control group according to grouping time, 25 in each group (30 hips). Patients in the control group were implanted with porous tantalum rod, while those in the treatment group additionally took GHC (5 pills each time, three time per day for 2 successive months; and then twice per day for 4 successive months). Then all patients were followed-up to observe Harris hip score. The curative effect and the femoral head survival time were assessed.</p><p><b>RESULTS</b>A total of 49 patients (59 hips) were followed-up. The Harris hip score of the two groups at the final follow-up was significantly improved after treatment, with statistical difference when compared with before treatment (P < 0.01). Besides, it was higher in the treatment group than in the control group. The curative effect and the survival time were superior in the treatment group, with statistical difference when compared with the control group (P < 0.05).</p><p><b>CONCLUSIONS</b>Porous tantalum rod combined GHC got better effect in treating SONFH. It could significantly improve the function of affected hips and prolong the survival time of femoral head.</p>

Application of minimally invasive, decompression bone graft implantation combined with metal trabecular bone reconstruction system for early stage osteonecrosis of femoral head / 中国骨伤

<p><b>OBJECTIVE</b>To observe the application effect of minimally invasive decompression, bone graft implantation and metal trabecular bone reconstruction system for early stage osteonecrosis of femoral head and discuss the treatment of hip-salvage operation in early stage osteonecrosis of femoral head;</p><p><b>METHODS</b>From January 2010 to June 2011, 50 patients (62 hips) Which were osteonecrosis of femoral head of early stake,were treated with minimally invasive decompression, bone graft implantation and metal trabecular bone reconstruction system, including 31 males (40 hips), 19 females (22 hip) with an average age of 36.2 years old ranging from 22 to 54 years old. The course of disease was from 6 to 15 months (averaged 10.5 months). Among them, 19 cases (23 hips) were steroid-induced, 25 cases (33 hips) were alcohol-induced, 6 cases (6 hips) were idiopathic; According to ARCO stage, 28 hips were at stage I, 34 hips were at stage II. All of them were diagnosed as femoral head necrosis by imaging examination before operation. Then each patient was followed to assess by Harris hip score, curative effect, and conduct the femoral head survival analysis during the postoperation.</p><p><b>RESULTS</b>All patients had finished operation, the operation time was between 30 and 85 min, intraoperative blood loss was 50 to 220 ml, and 47 cases (58 hips) were follow-up from 24 to 46 months with an average of 34.05 months. As compared with preoperative, the Harris hip score at the last follow-up was improved, the difference was statistically significant (P<0.01). The Harris hip score, curative effect and survival time of femoral head in ARCO stage I was superior to these in ARCO Stage II, the difference was statistically significant (P< 0.05).</p><p><b>CONCLUSION</b>Effect of minimally invasive decompression,bone graft implantation combine with the metal trabecular bone reconstruction system for early stage osteonecrosis of femoral head was good,it could significantly improve the Harris hip score, increase the femoral head survival time, delay the hip replacement, and performance better in ARCO stage I.</p>