RESUMO
bjective: To investigate the efficacy of pemetrexed as a second-line treatment for patients with NSCLC (advanced non-small cell lung cancer). Methods: Fifty-six patients with stages III B-IV NSCLC, who failed in the first-line cisplatin-based chemotherapy, were enrolled in this study between January 2008 and January 2012. All the patiients received pemetrexed 500 mg/m2 on day 1 and repeated every 21 days as a second-line chemotherapy. After two cycles of chemotherapy, the clinical efficacy and the adverse effects were evaluated. The median survival time and the one-year survival rate were calculated. Results: All the patients received 2-6 cycles of the chemotherapy with a total of 178 cycles. All patients were evaluable. Of the 56 patients, no one achieved complete response, 9 (16.1%) achieved partial response, 10 (33.9%) achieved stable disease, 28 (50.0%) achieved progressive disease. The objective response rate was 16.1% (9/56). The median survival time was 8.9 months, and the one-year survival rate was 30.35%. The common adverse effects were bone marrow suppression and gastrointestinal toxicities with a light severity and could be tolerable. No treatment-related deaths occurred. Conclusion: Chemotherapy with pemetrexed as a second-line treatment for advanced NSCLC has a definite efficacy, and the adverse effects can be tolerable. Copyright © 2013 by TUMOR.
RESUMO
Objective To explore the distribution and risk factors of injuries among home-stranded children and living in rural area of Anhui province and to provide basic information for the development of injury intervention program.Methods 3617 students were recurited from Changfeng county of Anhui province with stratified sampling method and a survey was conducted using questionnaires.Unconditional univariate and multivariate logistic regression analysis were performed to evaluate the situation of unintentional injuries among 1614 home-stranded children during the past one year and on its influencing factors.Results The number of home-stranded children accounted for 45.83%of the total number of students with the main type of guardianship was single-parent(55.82%).The incidence of injuries of students was 32.25%.The incidence of injuries of boys(36.43%)was higher than that of girls (27.44%)(χ2=32.340,P=0.000).The incidence of injuries among children was 32.25%but among children away from it was 40.90%,significantly higher than that of children with parents(24.95%)(χ2=101.730,P=0.000).Seven kinds of injures including fall,transportation or animal-related factor for children who were away from their parents,were higher than that of children with parents around.Data from Univariate analysis showed that injuries of children without family around were associated with gender,monthly income,education level of mother,type of guardianship,introversion-extroversion,neuroticism, cohesion, conflict, independence, active-recreational orientation, intellectual-cultural orientation.Results from multivariate analysis indicated that injuries of home-stranded children were associated with gender(OR=0.598),being the only child(OR=1.445),introversion-extroversion (OR=1.062),cohesion(OR=0.933),conflict(OR=1.150),independence(OR=1.110),intellectual-cultural orientation(OR=0.928),active-recreational orientation(OR=1.096)and ability of self-control(OR=0.917).Conclusion Many factors were found to be involved in injuries among children who were away from parents,especially regarding family environment and the individual personality.Special preventive measures should be taken to reduce the incidence of injuries among rural children who were away from their parents.