Content and antioxidant activity of total polyphenols and tannins from Athyrium multidentatum (Doll.)Ching / 国际中医中药杂志

Objective To determine the content and to evaluate the antioxidant activity of total polyphenols and tannins from Athyrium multidentatum(Doll.)Ching rhizome. Methods Folin phenol reagent?casein method was used to determine the content of total polyphenols and tannins. Spectrophotometry was used to evaluate the antioxidant activity. Results The content of total polyphenols and tannins was 24.61%and 4.59%, respectively. The total polyphenols and tannins exhibited strong reducing power and hydroxyl radicals/superoxide radicals scavenging capability. Conclusion The antioxidant activity of total polyphenols and tannins from Athyrium multidentatum(Doll.)Ching rhizome is significant and further investigation is deserved in the future.

Clinical analysis of pediatric testicular benign tumors / 南方医科大学学报

<p><b>OBJECTIVE</b>To explore the diagnosis, treatment and prognosis of testicular benign tumors in children.</p><p><b>METHODS</b>The clinical data of 37 boys (aged between 3 months to 12 years) with testicular tumors treated in our center between August 2000 and August 2013 were retrospectively analyzed. The median age was 14 months and 21 boys were less than 2 years old. The tumors were on the left side in 18 cases, on the right side in 15 cases, and on both sides in 4 cases (adrenal residue testis tumor). Thirty-five patients presented with painless scrotal mass; in the other two cases, testicular residue tumor was found in routine medical examination in one case and testicular mature teratoma was found due to perineal pain in the other; both of the boys underwent ultrasound or CT examination. Thirty-three boys had tumor marker detection. Of the 37 boys with benign testicular tumors, 25 underwent radical inguinal orchiectomy and 12 had testis-sparing surgery.</p><p><b>RESULTS</b>The boys were followed up for 3-107 months (median 46 months). No patients were found to have tumor recurrence, metastasis or such complications as testicular atrophy; 3 boys had natural fertility later in adutthood.</p><p><b>CONCLUSIONS</b>A high proportion of testicular tumors in children are benign. Preoperative ultrasound or CT combined with detection of tumor markers such as serum AFP can be important in the diagnosis of pediatric testicular tumors, for which testis-sparing surgery should be considered.</p>

Simvastatin ameliorates rat ventricular remodeling after myocardial infarction:the role of phosphorylating extracellular signal-regulated kinase1/2 / 中国药理学通报

Aim To study the effect of simvastatin on ventricular remodeling in rats after myocardial infarction,and the association between this effect and phosphorylating extracellular signal-regulated kinase1/2(p-ERK1/2).Methods Myocardial infarction(MI)rat models were successfully induced by ligation of anterior descending coronary artery.The treated rats were randomly divided into 4 groups(n=8~10):MI only group,MI plus 20 mg Sim group(20 mg?kg-1?d-1),MI plus 40 mg Sim group(40 mg?kg-1?d-1),and sham-operated group.After 4 weeks,the rats were checked by echocardiography including LVEDd,LVPWd,LVEF,FS,SV and CO.Myocardial p-ERK1/2 was also examined by immunohistochemistry and Western blot.Results Compared with sham-operated group,LVEDd,LVPWd in other groups were significantly increased(P