Preliminary report on the influence of HLA classⅡ molecules on outcome of hepatitis B virus infection in Zhejiang district / 中华传染病杂志

Objective To investigate correlation between HLA classⅡ molecules and the different outcome of viral hepatitis B. Methods Thirty patients with chronic hepatitis B and 56 subjects who had spontaneously recovered from HBV infection in Zhejiang district were enrolled in this investigation. HLA classⅡ molecule types and their alleles were determined by PCR ssp. Results HLA DR12 was found in 21 of 56 subjects recovered from hepatitis B (38%), compared to 3 of 30 patients with chronic hepatitis B (10%, rr 0.19; P corr