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Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 975-978, 2014.
Artigo em Chinês | WPRIM | ID: wpr-746507

RESUMO

OBJECTIVE@#To filtrate and prove the different microRNAs (miRs) profiles in nasopharyngeal carcinoma.@*METHOD@#Screening the different expressions of miRs between nasopharyngeal carcinoma and the inflammatory tissues by the application of expression profiling of chip high-throughput and large-scale microarray analysis. Then we used RT-QPCR technology to prove the accuracy of screening results.@*RESULT@#There were significant expression differences of miRs between nasopharyngeal carcinoma and the control tissues, 144 human miRs had 2 or more fold the difference ratio. Compared with the inflammatory tissues, we have found that miRs-34b, miRs-449b and miRs-7-1 significantly low expressed in nasopharyngeal carcinoma, yet miRs-125b, miRs-184, miRs-196b, miRs-205 and miRs-24-1 expressed high. The results were consistent with the microarray analysis.@*CONCLUSION@#The difference expressed miRs might be closely related to the process of nasopharyngeal carcinoma, and the research on miRs profiles maybe provide a powerful target basis for early diagnosis and therapy of nasopharyngeal carcinoma.


Assuntos
Humanos , Carcinoma , Perfilação da Expressão Gênica , MicroRNAs , Genética , Carcinoma Nasofaríngeo , Neoplasias Nasofaríngeas , Genética , Análise de Sequência com Séries de Oligonucleotídeos
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