RESUMO
Objective To observe the clinical value of neutrophil VCS parameters in the patients with zinc oxide toxicosis.Methods The peripheral blood samples from 120 patients with zinc oxide toxicosis,50 patients with bacteria infection and 60 healthy subjects were tested using Coulter LH 750 hematology analyzer.VCS parameters,including mean neutrophil volume (MNV),neutrophil distribution width (NDW),mean neutrophil conductivity (MNC) and mean neutrophil scattering value (MNS),were examined before and after treatment.Results MNV in patients with zinc oxide toxicosis increased significantly compared with those of healthy group and bacterial-infectious group.On the contrary,MNC decreased significantly in the patients with zinc oxide toxicosis compared with that of healthy group and bacterial infection patients.There was significant statistical difference between the two groups (P ＜ 0.01).When the cut-off value is less than 144.70,the sensitivity and specificity of differential diagnosis are 90.83％,98.33％,respectively,higher than those of WBC count and other VCS parameters.The values of MNC in WBC greater than or equal to 10.0 × 109/L group and WBC less than 10.0 × 109/L group were (140.05 ±4.26) and (138.87 ±5.87) respectively.There was no significant difference between the two groups (P ＞ 0.05).The values returned to normal range after treatment for 3 days.Conclusion The MNC of neutrophil may reflect the morphologic change of neutrophils in zinc oxide toxicosis and restore its normal value after treatment,so it can be used as a marker for diagnosis and monitoring of disease.