RESUMO
Objective: the effect of xylazine-ketamine on cardiovascular system and respiratory system was evaluated by measurement of arterial blood pressure, blood gases, temperature, heart and respiratory rate
Design: self-controlled study
Animals: five healthy sheep with an average weight of 21.4 kg were used in this study
Procedure: xylazine [0.2 mg/kg IM] was administrated 15 minutes prior to utilization of ketamine [10 mg/kg IV] in all animals. All baseline measurements [heart rate, respiratory rate and .] were taken before the xylazine administration and were taken again at 5, 15, 30, 45 and 60 minutes intervals after induction of anesthesia with ketamine. Arterial catheters flushed with 2:1000 heparin solution were placed by using local anesthesia into the carotid artery via a 5 cm skin incision for measuring arterial blood pressure and collecting blood samples
Statistical analysis: repeated measure analysis of variances design and least significant difference were used to analyze data
Results: on the basis of these results, heart rate did not change significantly. Mean arterial blood pressure decreased significantly at 30, 45, and 60 minutes after anesthesia. PaO2 declined significantly at 60 minutes and PaCO2 at first increased at 5 minute, then decreased at 15, 30, 45, and 60 minutes but remained significantly higher than before anesthesia, but respiratory rate did not change significantly. Temperature declined significantly at 5, 15, 30, 45 and 60 minutes after anesthesia
Conclusion: according to this study, xylazine-ketamine combination has a little depressant effect on cardiovascular system. This combination is responsible for a little disturbed ventilation, decreased PaO2, increased PaCO2 and declined body temperature in anesthesia