new antidiabetic drug restoring normal insulin secretion from beta-cells and normal histology

A benzimidazole derivative was prepared and evaluated as antidiabetic drug. It was found to be nontoxic to albino mice up to dose of 3200 mg/kg body weight. It had no hypoglycemic activity but it was found to cause beta-cell regeneration in alloxanoised rats. Measuring blood glucose levels and insulin levels in treated alloxanoised rats were found to reach normal levels after treatment. In addition histological examination of the pancreas from treated alloxanoised rats showed normal islets of langerhans with normal morphology of beta-cells

Novel synthesis of furoindole pyridone, pyrazolone and cyanoacethydrazide derivatives from isatin

Isatin I reacted with diethyl 2-amino-1-cyanopropen-1,3-dicarboxylate IIa and with 1,1-dicyano-3-carbethoxy-2-aminoprop-1-ene IIb to give the corresponding 3-substituted furoindole derivatives IV. Compound IVa reacted with malononitrile and ethylcyanoacetate to give the 3- substituted-pyridine and pyridone derivatives VI and VIII, respectively. The reaction of isatin with cyanoacethydrazine afforded IX which was cyclised to aminopyrazolone derivative X on boiling its solution in ethanol/triethylamine. Similarly, treatment of istain I with methylpyrazlinone afforded the corresponding derivative XII