RESUMO
Objective@#To analyze the prevalence of latent infection of pathogens of hand,foot and mouth disease (HFMD) in Chinese healthy population and its influencing factors,so as to provide reference for the prevention and control of HFMD.@*Methods @#Literature on the latent infection of HFMD was searched in Chinese and English databases,such as CNKI,Wanfang,CBMd,PubMed,Web of Science and ScienceDirect,from January 1,2000 to December 31,2019. The pooled rate and its 95% confidence interval(95%CI)were used to assess the latent infection rate of HFMD pathogens in healthy Chinese population.@*Results@#A total of 442 articles were retrieved,and 31 articles were finally included in the quantitative meta-analysis. The results showed that the latent infection rate of human enteroviruses in healthy Chinese population was 18.8%(95%CI:16.1%-21.6%),and the latent infection rates of EV71,CV-A16 and other HEVs were 3.7%(95%CI:2.5%-4.9%),1.9%(95%CI:1.0%-2.9%) and 15.1%(95%CI:11.9%-18.3%),respectively. The latent infection rates of HEVs in healthy men and women in China were 16.7%(95%CI:12.9%-20.4%) and 14.4%(95%CI:10.8%-18.0%),respectively. The latent infection rates of human enterovirues HEVs in the healthy population aged 0-5 years and over 5 years were 24.4%(95%CI:20.4%-28.5%) and 9.4%(95%CI:6.5%-12.2%),respectively. Meta regression analysis showed that the associated factors for the latent infection rate of HEVs in Chinese healthy population included sampling period,sampling area and study population.Sensitivity analysis showed that there was no significant change on meta results after the exclusion of individual studies one by one(p>0.05). Begg's tests,Egger's tests and funnel plots all indicated the existence of publication bias. Trim and fill method showed that the recessive infection rate was reduced after adjustment(p<0.05). @*Conclusions@#The latent infection rate of HFMD pathogens is high in healthy people in China,and it is mainly caused by other HEVs. Males and children aged under 5 years are at high risk of latent infection of HEVs.
RESUMO
Objective@#To learn anxiety and depression status in junior high school students with myopia in Zhoushan and their influencing factors,so as to provide reference for vision care and mental health intervention.@*Methods@#A stratified cluster random sampling method was used to select students from two junior high school in Zhoushan. A self-designed questionnaire,self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were employed to collect the demographic information,and to evaluate anxiety and depression status.The logistic regression analysis was used to select the influencing factors for anxiety and depression in myopia students.@*Results @#A total of 775 questionnaires were sent out and 766 valid ones were recovered,with an response rate of 98.84%. There were 662 students with myopia.The rates of anxiety,depression and the two combined in myopic students were 22.36%,25.38% and 14.35%,respectively.The results of the multivariate logistic regression analysis showed that the risk factors for anxiety of myopic students were females (OR=1.514,95%CI:1.054-2.183),the third grade (OR=2.246,95%CI:1.408-3.619),high myopia (OR=1.839,95%CI:1.126-3.017) and wearing glasses for two years or above (OR=2.504,95%CI:1.464-4.306); the risk factors for depression were females (OR=1.182,95%CI:1.253-2.536),above average of school record (OR:1.614-2.026,95%CI:1.034-3.153),high myopia (OR=2.284,95%CI:1.513-3.436) and wearing glasses for two years or above (OR=4.602,95%CI:2.035-10.372). @*Conclusions@#The prevalence rates of anxiety and depression are higher in junior high school students with myopia in Zhoushan. The students who are females,are in the third grade,have above average of school record,have high myopia and wearing glasses for two years or above are more likely to suffer from anxiety or depression.