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AIM: To investigate the efficacy and safety of 577nm subthreshold micropulse laser(SML)in patients with chronic central serous chorioretinopathy(CSC).METHODS: Prospective single-arm case study. There were 24 patients(32 eyes)with chronic CSC treated by using 577nm SML. A total of 6mo was followed up after treatment, the best corrected visual acuity(BCVA, LogMAR)and optic coherence tomography(OCT)were performed at each month. Fluorescein fundus angiography(FFA)was performed at 1,3 and 6mo after treatment.RESULTS: The BCVA was 0.46±0.34 and central retinal thickness(CRT)was 259.15±57.54μm of 32 eyes at baseline period. After treatment of SML at 1mo, there was no subretinal fluid in 21 eyes(66%), and subretinal fluid was observed in 11 eyes(34%). The BCVA was 0.43±0.27, the CRT was 232.13±42.58μm. CRT was significantly reduced compared to the baseline period(P<0.05). After treatment of SML at 3mo, subretinal fluid and fluorescein leakage from retinal pigment epithelium(RPE)were observed in 5 eyes(16%). The BCVA was 0.39±0.26 and CRT was 231.26±49.25μm. The CRT was still significantly lower than baseline period(P<0.05). The 5 eyes with subretinal fluid and leaked fluorescein were treated by using SML again. After treatment at 6mo, subretinal fluid was observed in only 3 eyes(9%). The BCVA was 0.19±0.47 and CRT was 217.25±35.54μm. Both of the BCVA and CRT showed a significant improvement from the baseline period(P<0.05). CONCLUSION:SML seems effective and safe for treatment of chronic CSC. It may be an alternative way for treatment of chronic CSC.
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Objective To compare the accuracy of spectrophotometer under different color measurement conditions, so as to provide evidence for clinical color measurement. Methods Spectrophotometer was used to obtain the chromatic value L*, a* and b*(L*:Lightness; a*:Saturation on the red and green axile; b*:Saturation on the yellow and blue axile) of all color pieces in the medium 1/3 of vita classical shade guide under the natural light, incandescent lamp and dark room; the values of chromatism were calculated under different color measurement conditions, and the results were fed to statistical software for analysis. Results The L*, a* and b* values were not significantly different under natural light, incandescent lamp and dark room. The composition ratios of ΔE <1.5 NBS for the natural light and incandescent light, natural light and dark room, incandescent lamp and dark room were 87.50%, 100%, and 93.75%, respectively. Conclusion The measurement accuracy of CM-700d spectrophotometer is high and the environment light has slight effe0ct on the accuracy. The chromatism values of shade guide measured in the dark room is the most true ones, so dark room is recommended for CM-700d spectrophotomete.