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1.
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 519-523, 2009.
Artigo em Chinês | WPRIM | ID: wpr-273657

RESUMO

<p><b>OBJECTIVE</b>To evaluate the effect of Qufeng Zhidong Recipe (QZR) on the head tic behavior, and the mRNA expressions of Notch1 and dopamine D2 receptor (D2R) in tic disordered mice.</p><p><b>METHODS</b>Mouse model like wet-dog shake head tic disorder was established by peritoneal injection of 5-HT2A/C agonist DOI for 14 successive days. The model mice were divided into three groups, the model group, the Chinese medicine (CM) treated group and the Western medicine (WM) treated group, they were intervened respectively with distilled water, QZR (10 g/kg) and haloperidol (1 mg/kg). Besides, a normal control group was set up and gastrogavaged with distilled water. The effect of intervention was evaluated 2 weeks later by estimating the head tic and the creeping distance of animals, and the mRNA expressions of D2R and Notch1 in corpus striatum and prefrontal cortex regions were detected using Real-time PCR.</p><p><b>RESULTS</b>The wet-dog shake response and the creeping distance of mice were significantly reduced after intervention in both intervened groups, showing insignificant difference between the effects of CM and WM (P > 0.05). The expression of D2R mRNA in corpus striatum was higher than that in the prefrontal cortex (P < 0.01), at the prefrontal cortex, it was 151 +/- 30 in the CM group and 180 +/- 41 in the WM group, and at the corpus striatum, 710 +/- 64 and 850 +/- 80 respectively, all higher than those in the model group (P < 0.05). While the Notch1 mRNA expression in model mice were lower at the prefrontal cortex than at the corpus striatum (P < 0.05). After intervention it was 55 +/- 20 in the CM group and 48 +/- 23 in the WM group at the prefrontal cortex, all significantly lower than that in the model group (P < 0.05).</p><p><b>CONCLUSION</b>DOI-induced wet-dog shake response could well simulate the clinical characteristics of tic disorder; QZR could improve the tic behavior and creeping distance in the model mice. The up-regulation of D2R mRNA expression after QZR intervention may be related with the down-regulation of Notch1 expression, this findings is worthy of further studies.</p>


Assuntos
Animais , Masculino , Camundongos , Corpo Estriado , Metabolismo , Medicamentos de Ervas Chinesas , Usos Terapêuticos , Camundongos Endogâmicos C57BL , Fitoterapia , RNA Mensageiro , Genética , Metabolismo , Distribuição Aleatória , Receptor Notch1 , Genética , Metabolismo , Receptores de Dopamina D2 , Genética , Metabolismo , Transdução de Sinais , Transtornos de Tique , Tratamento Farmacológico
2.
Chinese journal of integrative medicine ; (12): 254-260, 2009.
Artigo em Inglês | WPRIM | ID: wpr-345002

RESUMO

<p><b>OBJECTIVE</b>To assess the effect and adverse reaction of Qufeng Zhidong Recipe (QZR) in treating children's tic disorder (TD).</p><p><b>METHODS</b>With multicenter randomized parallel open-controlled method adopted, the patients enrolled were assigned to two groups, 41 cases in the Chinese medicine (CM) group and 40 in the Western medicine (WM) group. They were treated by QZR and haloperidol plus trihexyphenidyl respectively for 12 weeks as one course. In total, two courses of treatment were given. The curative effect and adverse reactions were evaluated by scoring with Yale Global Tic Severity Scale (YGTSS), Traditional Chinese Medicine Syndrome Scale (TCMSS), and Treatment Emergent Symptom Scale (TESS), as well as results of laboratory examinations.</p><p><b>RESULTS</b>After one course of treatment, the markedly effective rate in the CM and the WM group was 14.6% and 17.5%, respectively, and the total effective rate 43.9% and 47.5%, respectively, which showed insignificant difference between groups (P>0.05). However, after two courses of treatment, markedly effective rate in them was 73.2% and 7.5%, and the total effective rate was 100.0% and 57.5%, both showing significant differences between groups (P<0.05). Besides, the adverse reactions occurred in the CM group was less than that in the WM group obviously.</p><p><b>CONCLUSION</b>QZR has definite curative effect with no apparent adverse reaction in treating TD, and it can obviously improve the symptoms and signs and upgrade the quality of life and learning capacities in such patients.</p>


Assuntos
Criança , Pré-Escolar , Feminino , Humanos , Masculino , Antiparkinsonianos , Antipsicóticos , Livros de Culinária como Assunto , Quimioterapia Combinada , Medicamentos de Ervas Chinesas , Usos Terapêuticos , Haloperidol , Transtornos de Tique , Tratamento Farmacológico , Resultado do Tratamento , Triexifenidil , Ocidente
3.
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 441-444, 2005.
Artigo em Chinês | WPRIM | ID: wpr-234853

RESUMO

<p><b>OBJECTIVE</b>To study the effect of sour TCM compound Recipe (SCCR) on insulin resistance in experimental rats with diabetes mellitus type 2 (DM2), under the guidance of TCM doctrine of "sour restrains sweet".</p><p><b>METHODS</b>Model rats of DM2 were established by 8 weeks' feeding with high calorie forage combined with intraperitoneal injection of small dose of streptozotocin, and treated with SCCR (15 g/kg of crude drug/day). Levels of fasting blood glucose (FBG), serum insulin, free fatty acids (FFA), tumor necrosis factor a (TNF-alpha), combining capacity and constant of insulin receptor in liver were determined before treatment and 4, 8 and 12 weeks after treatment, and the insulin sensitive index was calculated. The data were compared with those in the model group (untreated), sweet TCM compound recipe group and bitter TCM compound group (treated with sweet and bitter Chinese drugs respectively) and the control group (treated with dimethyldiguanide).</p><p><b>RESULTS</b>SCCR could markedly reduce the FBG, serum FFA and TNF-alpha levels in rat model of DM2, stimulate the secretion of insulin, raise the combining capacity and constant of insulin receptor in liver and improve the insulin sensitivity, as compared with the effect of sweet or bitter Chinese compound recipe, the difference was significant (P < 0.05).</p><p><b>CONCLUSION</b>SCCR could improve the glucose metabolic disorder and ameliorate the degree of insulin resistance in DM2 model rats, with the effect superior to those with sweet or bitter taste, which illustrates primarily that the therapeutic principle of "sour restrains sweet" of TCM is true of science in a certain degree and having its guiding significance in clinical practice.</p>


Assuntos
Animais , Masculino , Ratos , Diabetes Mellitus Experimental , Tratamento Farmacológico , Diabetes Mellitus Tipo 2 , Tratamento Farmacológico , Composição de Medicamentos , Medicamentos de Ervas Chinesas , Usos Terapêuticos , Resistência à Insulina , Fitoterapia
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