Study on clinical efficacy of zhennaoning capsules in treatment of cerebral arteriosclerosis and analysis on its economic benefits / 中国中药杂志

To study clinical efficacy of Zhennaoning capsules in treating cases with cerebral arteriosclerosis, and analyze its economic benefits. Totally 254 cases with cerebral arteriosclerosis were randomly divided into two groups according to their doctor-consulting sequence: the test group (n = 128) that was administered with Zhennaoning capsules, and the control group (n = 126) that was administered with Yangxueqingnao granules. A double-blind parallel-controlled study was conducted for four weeks, in order to observe the clinical efficacy and adverse effects of the two groups, and evaluate their pharmacoeconomics. Additionally, the clinical efficacy and safety of Zhennaoning capsules in treating cerebral arteriosclerosis, as well as its pharmacoeconomics were also discussed. This study showed that Zhennaoning capsules had a better efficacy than its control drug Yangxueqingnao granules in relieving traditional Chinese medicinal syndromes (according to traditional Chinese medicinal syndrome coring, efficacy and cure rate), suggesting a statistical significance (P < 0.01). Despite statistical significance showed from the differences in the remaining indexes and the occurrence rate of adverse effects, the test group displayed a lower cost effectives than the control group (P < 0.01). Zhennaoning capsules have a better clinical efficacy in treating cases with cerebral arteriosclerosis than Yangxueqingnao granules, demonstrating safe clinical application and better economic advantages.

Advance of studies on interaction between active components of natural medicines and lysozymes / 中国中药杂志

Lysozyme (LYSO), as an alkalescent protein micromolecule in living organisms, exhibits important pharmacological actions such as antibiosis, anti-inflammatory, antivirus and enhancing immunity. LYSO can combine with many exogenous and endogenous substances and carry many drugs. This essay summarizes interaction between different kinds of active components of natural medicines and lysozymes, which is significant to comprehensively understand pharmacological mechanism of natural drugs and their transfer and metabolic process in organisms, optimize molecule structures of drugs and increase bioavailability and biological effects of natural drugs.

Systhesis of magnetic thermosensitive hydrogel and its heat effect under alternating magnetic field / 中国药学杂志

OBJECTIVE: To synthesize magnetic thermosensitive hydrogel and study its heat effect under alternating magnetic field in vitro. METHODS: PLGA-PEG-PLGA triblock copolymer was synthesized by ring-opening polymerization of D, L-lactide and glycolide with PEG1500 in the presence of stannous iso caprylate. Magnetic thermosensitive hydrogel of different concentrations were prepared using different currents. The influences of the concentration of magnetic fluid and current of magnetic field on the heat effect were separately observed. RESULTS: The synthetized PLGA-PEG-PLGA triblock copolymer was excellently temperature sensitive. It retained the thermo-sensitivity of original hydrogel when the magnetic fluid was loaded. The 5, 10 and 20 min heating ability of magnetic fluid was positively linearly correlated with its concentration (r=0.9985, 0.9893 and 0.9711, respectively, n=3) and current of magnetic field (r=0.9948, 0.9977 and 0.9994, respectively, n=4). CONCLUSION: The magnetic thermosensitive hydrogel has excellent temperature sensitivity. When alternating magnetic field is applied, the temperature of the system can rise and reach above LCST of hydrogel. The temperature can be controlled by changing the concentration of magnetic fluid and the current of magnetic field. Copyright 2012 by the Chinese Pharmaceutical Association.