RESUMO
The composition of intestinal microflora is closely related to the occurrence and development of colorectal cancer (CRC). Among them, Fusobacterium nucleatum (Fn) has been proved directly related to the recurrence, metastasis and chemotherapy resistance of CRC. Therefore, it is of great significance for the prevention and treatment of colorectal cancer by the exploration potential anti-Fn drug targets and discovery small molecule drugs. However, no selective anti-Fn small molecule inhibitors have been reported so far as well as their anti-Fn thereby "anti-Fn further anticancer" mechanisms are unclear. Herein, this article reviews the potential therapeutic targets and small molecule ligands of Fn in order to provide a reference for the development of anti-Fn and anti-CRC small molecule drugs.
RESUMO
This paper is a summary of the progress of botanical research in Dioscorea zingiberensis. It contains biological characteristic, genetic diversity, growth circumstance, breeding, cultivating, tissue and cell culture of D. zingiberensis. According to the fact of market demanding and resources protection, the writers propose that some work, including establishing gene bank, resources appraise, employing advanced technology to utlize the resources and making the cultivated standard, should be taken into consideration.