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Asian Pac J Allergy Immunol ; 1996 Dec; 14(2): 81-5
Artigo em Inglês | IMSEAR | ID: sea-36538

RESUMO

Scleroderma is a systemic connective tissue disease in which the diagnosis in supported by morphological changes in nailfold capillary size and density. These changes are open to observer bias. In this paper we describe 2 objective methods that allow quantitative definition of capillary changes, video image analysis (VIA) and photomicroscopy. VIA was used to assess 15 healthy control subjects and 22 patients with scleroderma. Scleroderma patients had a significantly larger capillary diameter (43 microns versus 20 microns, p = 0.0001) and capillary density was reduced by a mean factor of 0.5. Image stored on computer will facilitate serial assessments of nailfold capillary changes and possibly provide information on disease progression.


Assuntos
Adulto , Idoso , Idoso de 80 Anos ou mais , Envelhecimento , Capilares/patologia , Feminino , Humanos , Masculino , Microscopia de Vídeo , Pessoa de Meia-Idade , Unhas/irrigação sanguínea , Fotomicrografia , Escleroderma Sistêmico/patologia , Caracteres Sexuais
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