A Comparative Study Of Onset Time And Intubating Condition For Different Dose Of Rocuronium In Burn And Non-Burn Patients

An aberrant pharmacodynamics responses to neuromuscular blocking drugs(NMBD)in burn patients increases the potential for lethal hyperkalemia with the administration of depolarizing muscle relaxant eg:succinylcholine and 2.5–5 folds increase in the dose of plasma concentration requirement for non–depolarizing muscle relaxants like :D–tubocurarine,metacurine,pancuronium,atracurium,vecuronium.Therefore Rocuronium may be the drug of choice in burn patients.This study was planned to assess the onset time and intubating conditions with two different doses of rocuronium in patients with thermal injury.It was concluded that in non–burn patient onset time(loss of response to TOF) was 85.5�4.8 sec with a dose of 0.9 mg/kg as compared to 1.2 mg/kg it was 60.55�70.4,while in burn patients (more than 30% burn area) these values were 120.83�6.81 sec and 86.16�5.2 respectively.

Importance of Neem Leaf: An insight into its role in combating diseases.

The neem (Azadirachta indica A. Juss) is a tropical evergreen tree (Fam. Meliacae; Subfam. Melioideae) traditionally well known for its medicinal value. Beneficialt effects of different parts of neem are attributed to its biologically active principle ‘Azadirachtin’. Apart from Indian subcontinent, neem is widely used in African countries as therapeutics, preservatives and insecticides. Neem leaves, natural source of flavonoids, polyphenols, isoprenoids, sulphurous and polysaccharides, play important role in scavenging the free radical and subsequently arresting disease pathogenesis. Considerable research has gone into neem for developing cost effective and non-toxic products. The present review has compiled different phytochemicals isolated from neem leaves, methods of extraction and their therapeutic use in preventing several diseases. Here, we highlighted the mechanism of anti-inflammatory and antioxidant activity of neem leaf that underscores the disease through regulation of physiological responses. Also, multiple roles of neem leaf and commercial use of neem formulation as an alternative in paving a frontier in the field of drug discovery are discussed.