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Pidotimod is a synthetic dipeptide, which has immunomodulatory property. It is used in recurrent upper respiratory tract infections, where there is nonspecific immune deficiency, especially in children who are more prone to recurrent respiratory infections. This article discusses its structure, pharmacokinetics including mechanism of action and clinical uses. A brief review of literature has been carried out. Possible future application is suggested.
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Background: Corona virus disease 2019 pandemic (COVID-19), has posed significant mental health challenges. Psychological morbidities among Indian doctors has not been extensively examined. In order to plan appropriate interventions, it is imperative to know the details of the mental health condition of our doctors especially so during this period of enormous physical and mental challenges brought by the current pandemic. Methodology: The present findings, are from an online survey done to briefly assess the mental health status of doctors. The survey was done, through a questionnaire, generated by the authors, from items of Mini International Neuropsychiatric Interview (MINI) version 6. Results: A total of 274 responses were received and 242were analysed. Mean age of the participants was 37.21 Years (SD = 10.70). 61.98% of the participants were males. 42.14% were resident doctors, 44.21% were faculty members. Majority of the doctors reported having some psychiatric symptom. Only, 0.83% reported having suicidal ideation. None of the participants were planning to seek a psychiatric consultation, in near future, for the psychiatric problems. There was a positive correlation of psychiatric symptoms, with exposure to COVID-19 duties. Conclusions: Doctors have higher psychological morbidities, but due to various reasons are not willing to address the severity of their symptoms nor are they acknowledging the need for intervention. There is an urgent need, for acceptance and acknowledgement of the psychological problems being faced by this highly demanding, vulnerable population, especially so during the present crisis
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Breast cancer is the third most common cancer in human and the second leading cause of cancer death in woman. Selenium is an essential but an intriguing trace element. It has an important role in prevention of breast cancer via its antioxidant effect. An inverse relationship has been observed by many authors between serum selenium levels and development of cancer in humans as well as experimental animals. It has also been found to have preventive effect in doses of 100-200 µg/day. It also potentiates the effect of tamoxifen and doxirubicin.
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Alpha-tocopherol level was measured spectrofluorometrically in 279 healthy volunteers to establish reliable reference values and to compare possible sex and age-related differences. In the present study, men had higher tocopherol levels than women (p<0.05) and older subjects had lower values. This study provides reference values for alpha-tocopherol that may assist it evaluating the anti-oxidant defense.