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Clinicopathological data of 15 patients with pyloric early cancer and precancerous lesions, who received endoscopic submucosal dissection (ESD) in Zhejiang Cancer Hospital from March 2011 to January 2020 were retrospectively analyzed. Postoperative pathology showed 7 cases of low-grade intraepithelial neoplasia, 3 cases of high-grade intraepithelial neoplasia, and 5 cases of early gastric cancer. R0 complete resection was achieved in all patients. The mean operation time was 55.2 min (35-78 min). One patient had delayed postoperative bleeding, and no other complications such as bleeding, perforation or abdominal pain occurred in other 14 patients. No recurrence, metastasis or pyloric stenosis was found during the follow-up of 31.3 months (1-106 months). ESD is safe and effective for early cancer and precancerous lesions in the pylorus.
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Objective To assess the association between exposure to prenatal outdoor air pollution and preterm birth to provide evidence in setting up programs for prevention on premature birth.Methods Case-control studies regarding association between pregnant exposure to outdoor air pollution and preterm birth were collected.Data were analyzed with Stata 12.0.Results Ten articles including 48 556 cases and 548 495 controls were qualified for inclusion.Results from Meta-analyses showed pooled ORs for exposure to NO2,PM10,CO,PM2.5,and NO during the entire pregnancy were 0.960 (95％CI:0.935-0.985),1.068 (95％CI:1.035-1.103),1.122 (95％CI:1.078-1.168),1.110 (95％ CI:1.043-1.181) and 0.994 (95％ CI:0.973-1.016).Association between air pollution and preterm birth varied with the periods of exposure.Pooled ORs for NO2,PM10 and SO2 exposure during the first trimester were 1.117 (95％CI:1.052-1.186),0.968 (95％CI:0.812-1.153) and 1.258 (95％CI:0.758-2.089).Pooled ORs for NO2,PM10,SO2 exposure during the second trimester were 1.000 (95％ CI:0.982-1.019),1.127 (95％ CI:0.896-1.416) and 0.977 (95％CI:0.711-1.342).Pooled ORs for NO2,PM10,SO2 exposure during the third trimester were 1.006 (95％CI:1.002-1.010),1.053 (95％CI:0.973-1.139) and 1.003 (95％CI:1.000-1.006).Conclusion Exposures to PM10,CO and PM2.5 during the entire pregnancy,to NO2 during the first trimester,or to NO2 and SO2 during the third trimester were associated with preterm births.
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Objective To assess the association between exposure to prenatal outdoor air pollution and preterm birth to provide evidence in setting up programs for prevention on premature birth.Methods Case-control studies regarding association between pregnant exposure to outdoor air pollution and preterm birth were collected.Data were analyzed with Stata 12.0.Results Ten articles including 48 556 cases and 548 495 controls were qualified for inclusion.Results from Meta-analyses showed pooled ORs for exposure to NO2,PM10,CO,PM2.5,and NO during the entire pregnancy were 0.960 (95％CI:0.935-0.985),1.068 (95％CI:1.035-1.103),1.122 (95％CI:1.078-1.168),1.110 (95％ CI:1.043-1.181) and 0.994 (95％ CI:0.973-1.016).Association between air pollution and preterm birth varied with the periods of exposure.Pooled ORs for NO2,PM10 and SO2 exposure during the first trimester were 1.117 (95％CI:1.052-1.186),0.968 (95％CI:0.812-1.153) and 1.258 (95％CI:0.758-2.089).Pooled ORs for NO2,PM10,SO2 exposure during the second trimester were 1.000 (95％ CI:0.982-1.019),1.127 (95％ CI:0.896-1.416) and 0.977 (95％CI:0.711-1.342).Pooled ORs for NO2,PM10,SO2 exposure during the third trimester were 1.006 (95％CI:1.002-1.010),1.053 (95％CI:0.973-1.139) and 1.003 (95％CI:1.000-1.006).Conclusion Exposures to PM10,CO and PM2.5 during the entire pregnancy,to NO2 during the first trimester,or to NO2 and SO2 during the third trimester were associated with preterm births.
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Objective To investigate the differences of measurement of gross target volume (GTV)between endoscopic ultrasonography ( EUS )-based ( GTVEUS ) and computed tomography ( CT ) -based (GTVCT) method for thoracic esophageal squamous cell carcinoma. Methods EUS was performed on 36consecutive patients with thoracic squamous cell carcinoma, and the superior and inferior boarders of the tumor defined by EUS were marked with hemoclips. The CT planning scan was then performed with the patient in supine position, and the GTVCT and GTVEUS were contoured respectively. The lengths ( LCT and LEUS) and spatial locations of longitudinal GTVCT and GTVEUS were compared. Results The mean LCT and LEUS were (7. 79 ± 3. 15 ) cm and (7. 42 ± 2. 72) cm, respectively ( t = 0. 82, P ＞ 0. 05 ), with a correlation coefficient of 0. 61 (P ＜0. 001 ). Locations of longitudinal GTVCT and GTVEUS were compared in 34cases, with 2 excluded for invisualization on CT. The mean conformal index (CI) was (0. 79 ± 0. 18 ), and spatial variations were found in 71% patients, with 8 patients at proximal end and 21 others at distal end.There was no clip placement associated complication. Conclusion Endoscopic hemoclips placement is safe and reliable. EUS can provide additional information to CT in defining longitudinal GTV in thoracic esophageal squamous cell carcinoma, especially in superficial and submucosal carcinomas.