Changes in HIV prevalence and intervention service utilization among MSM under sentinel monitoring in Taizhou of Zhejiang Province / 上海预防医学

ObjectiveTo analyze the changes in HIV， syphilis and hepatitis C prevalence among men who have sex with men （MSM） in Taizhou City， Zhejiang Province from 2017 to 2022， and the utilization of HIV intervention services and its influencing factors. MethodsMSM participants were recruited from HIV sentinel surveillance in Taizhou through snowball sampling method. Participants’ socio-demographic characteristics， sexual behavior characteristics， knowledge of HIV and utilization of HIV intervention services were collected and statistically described by questionnaire survey. Blood samples from MSM sentinel population were also collected for HIV， syphilis， and HCV antibody testing. Multivariate logistic regression analysis was used to analyze the influencing factors for utilizing HIV intervention services among MSM. ResultsA total of 2 499 MSM were included in the analysis from 2017 to 2022， with HIV prevalence of 5.8%， syphilis prevalence of 4.0%， and HCV prevalence of 0.6%. The infection rate， proportion of homosexual anal sex and heterosexual sex showed a decreasing trend， while the proportion of condom use during homosexual anal sex， condom publicity and distribution， AIDS consultation and testing， acceptance of peer education， and online temporary homosexual sex showed an increasing trend. All these differences were statistically significant. Multivariate logistic regression analysis showed that COVID-19 epidemic （aOR=1.66， 95%CI：1.04‒2.64） and HIV knowledge awareness （aOR=2.57， 95%CI：1.22‒5.40） were positively correlated with increased acceptance of condom publicity and distribution， and utilization of AIDS counseling and testing. Those who sought male sexual partners through offline route （aOR=3.44， 95%CI： 1.16‒10.21）， and had a history of sexually transmitted diseases within one year （aOR=5.47， 95%CI： 1.04‒28.76） were positively correlated with community-based methadone maintenance therapy， clean needle provision and exchange services， while COVID-19 epidemic （aOR=0.35， 95%CI： 0.14‒0.88） was negatively correlated with the utilization of these services. COVID-19 epidemic （aOR=2.11， 95%CI： 1.54‒2.89）， HIV knowledge awareness （aOR=2.09， 95%CI： 1.08‒4.02）， offline search for male sexual partners （aOR=1.47， 95%CI： 1.03‒2.11）， and awareness of HIV infection of sexual partners （aOR=2.09， 95%CI： 1.62‒2.69） were positively correlated with the increased use of peer education service， while married or cohabited （aOR=0.73， 95%CI： 0.55‒0.98） and VCT （aOR=0.61， 95%CI： 0.46‒0.82） were negatively correlated with utilization of peer education service. ConclusionHIV infection rate of sentinel MSM population in Taizhou decreases， while the utilization of HIV intervention services increases in general. Targeted measures should be developed according to the changes in sexual behavior and HIV intervention services among MSM populations in Taizhou to improve the HIV intervention services for the MSM population.

Efficacy of acarbose combined with metformin in the treatment of newly diagnosed type 2 diabetes mellitus with hyperlipidemia / 中国基层医药

Objective To observe the efficacy of acarbose combined with metformin in the treatment of newly diagnosed type 2 diabetes mellitus with hyperlipidemia. Methods 160 patients with newly diagnosed type 2 diabetes mellitus with hyperlipidemia were randomly divided into the observation group and the control group,80 cases in each group. The patients in the control group were treated with metformin alone. The patients in the observation group were treated with acarbose plus metformin. The changes of blood glucose and blood lipid index and the adverse reactions were observed before and after treatment. Results After treatment, the blood glucose and blood lipid index were significantly improved in both two groups compared with before treatment. Compared with the control group,the fasting blood glucose (FBG),postprandial 2h blood glucose (2hPG),glycosylated hemoglobin (HbAlc) levels in the observation group were significantly lower (t=5. 18,4. 16,8. 55,all P <0. 01). The total cholesterol (TC), triglyceride (TG),low density lipoprotein cholesterol (LDL-C) levels in the observation group were significantly lower than those in the control group (t=12. 97,7. 72,18. 77,all P<0. 01),the high density lipoprotein cholesterol (HDL-C) level was significantly higher than that in the control group (t=9. 64,P<0. 01). The total effective rate of blood glucose control in the observation group was 93. 7%,which was higher than 81. 3% in the control group,the difference was statistically significant (χ2 =5. 89,P<0. 05). Conclusion Acarbose combined with metformin in the treatment of newly diagnosed type 2 diabetes mellitus with hyperlipidemia has significant clinical efficacy, it is beneficial to control blood glucose and blood lipid level,and worthy of clinical application.

Efficacy of acarbose combined with metformin in the treatment of newly diagnosed type 2 diabetes mellitus with hyperlipidemia / 中国基层医药

Objective To observe the efficacy of acarbose combined with metformin in the treatment of newly diagnosed type 2 diabetes mellitus with hyperlipidemia. Methods 160 patients with newly diagnosed type 2 diabetes mellitus with hyperlipidemia were randomly divided into the observation group and the control group,80 cases in each group. The patients in the control group were treated with metformin alone. The patients in the observation group were treated with acarbose plus metformin. The changes of blood glucose and blood lipid index and the adverse reactions were observed before and after treatment. Results After treatment, the blood glucose and blood lipid index were significantly improved in both two groups compared with before treatment. Compared with the control group,the fasting blood glucose (FBG),postprandial 2h blood glucose (2hPG),glycosylated hemoglobin (HbAlc) levels in the observation group were significantly lower (t=5. 18,4. 16,8. 55,all P <0. 01). The total cholesterol (TC), triglyceride (TG),low density lipoprotein cholesterol (LDL-C) levels in the observation group were significantly lower than those in the control group (t=12. 97,7. 72,18. 77,all P<0. 01),the high density lipoprotein cholesterol (HDL-C) level was significantly higher than that in the control group (t=9. 64,P<0. 01). The total effective rate of blood glucose control in the observation group was 93. 7%,which was higher than 81. 3% in the control group,the difference was statistically significant (χ2 =5. 89,P<0. 05). Conclusion Acarbose combined with metformin in the treatment of newly diagnosed type 2 diabetes mellitus with hyperlipidemia has significant clinical efficacy, it is beneficial to control blood glucose and blood lipid level,and worthy of clinical application.

Nursing intervention on psychological status and life quality of patients with chronic heart failure / 中国实用护理杂志

Objective To observe the effect of nursing intervention on anxiety and depression status and life quality of patients with chronic heart failure (CHF). Methods 124 cases patients with CHF were randomly classified into the observation group and the control group with 62 cases in each group.The observation group was treated with nursing intervention,the control group was treated with routine nursing.The anxiety and depression status and life quality between the two groups were compared. Results Compared with pre-nursing,not only SAS and SDS score but also physical function,role function,emotional function,social function and quality of life in the observation group were significantly improved after nursing.However,there were no significant differences in the control group.Moreover,the scores of anxiety and depression and life quality were significantly better than those in the control group. Conclusions Nursing intervention for patients with CHF can improve anxiety and depression status and life quality of patients.

Comfort care on psychological status and life quality of patients in the interventional treatment of coronary heart disease / 中国实用护理杂志

Objective To observe the effect of comfort care on psychological status and life quality of patients undergoing interventional treatment of coronary heart disease. Methods 86 cases patients with coronary heart disease were randomly classified into the observation group and the control group with 43 cases in each group. The observation group was treated with comfort care and the control group was treated with normal nursing. The psychological status and life quality between the two groups were compared. Results Compared with pre-nursing, not only physiological function, independence, spiritual beliefs, social relations and quality of life but also SAS and SDS in the observation group were significantly improved after nursing. However, there were no significant differences in the control group. Moreover, the scores of life quality and anxiety and depression were significantly better than those in the control group. Conclusions Comfort care on patients with coronary heart disease can improve anxiety and depression status, servicing satisfaction and life quality of patients.