RESUMO
Objective @#To investigate the associations of the single nucleotide polymorphism ( SNP) rs2304733 in TEA domain transcription factor 1 ( TEAD1) , rs7135838 and rs1990330 in TEA domain transcription factor 4 (TEAD4) genes with the risk of non⁃cardia gastric carcinogenesis . @*Methods @#Enzyme linked immunosorbent assay ( ELISA) was used to detect specific antibodies against Helicobacter pylori(Hp)in serum samples of the normal control group . 470 normal controls were divided into Hp infection negative group (n = 223) and positive group ( n = 247) based on antibody titers . In the 450 non⁃cardia gastric cancer cases and 470 controls , polymerase chain reaction⁃restriction fragment length polymorphism (PCR⁃RFLP) was used to genotype the each SNP locus . The unconditional Logistic regression method was used to evaluate the associations between each SNP locus and the risk of non⁃cardia gastric carcinogenesis .@*Results @#The SNPs of TEAD1 and TEAD4 were not associated with Hp infection . TEAD1 rs2304733 was associated with the risk of non⁃cardia gastric cancer. Compared with the carriers of TT genotype , the carries of CT and CC genotypes had an increased risk of non⁃cardia gastric cancer (CT vs TT : OR = 2. 321 , 95% CI : 1 . 690 - 3 . 188 ; CC vs TT : OR = 5 . 140 , 95% CI : 1 . 080 - 24. 463) . TEAD4 rs1990330 was associated with the risk of non⁃cardia gastric cancer. Compared with the carriers of GG genotype , those with GT genotype had an increased risk of non⁃cardia gastric cancer ( OR = 2. 405 , 95% CI : 1 . 480 - 3 . 908 ) . TEAD4 rs7135838 was not associated with the risk of non⁃cardia gastric cancer. TEAD1 rs2304733 , TEAD4 rs7135838 and rs1990330 had interaction effects on the risk of non⁃cardia gastric cancer (P < 0. 05) . @*Conclusion @#In Baotou Han population , TEAD1 rs2304733 and TEAD4 rs1990330 do not play a major role in Hp infection , but may play a role in the risk of non⁃cardia gastric cancer. TEAD4 rs7135838 may not play a major role in the risk of Hp infection and non⁃cardia gastric cancer. TEAD1 rs2304733 and TEAD4 rs1990330 have the strongest synergistic effect on the risk of non⁃cardia gastric cancer , which is the best interaction model .