Influencing factors for drug-induced liver injury among patients with pulmonary tuberculosis in Ningbo City / 预防医学

Objective@#To investigate the factors affecting drug-induced liver injury among patients with pulmonary tuberculosis in Ningbo City from 2015 to 2019, so as to provide insights into the prevention of drug-induced liver injury.@*Methods@#Demographic features, presence of drug-induced liver injury, and disease history prior to anti-tuberculosis therapy were captured from patients with pulmonary tuberculosis in Ningbo City from 2015 to 2019 through the Tuberculosis Management Information System of the Chinese Disease Control and Prevention Information System and Ningbo Regional Diagnosis and Treatment Information Platform. Factors affecting drug-induced liver injury was identified using the multivariable logistic regression analysis.@*Results@#A total of 9 397 patients with pulmonary tuberculosis were enrolled, among whom 66.43% ( 6 242 case ) were male, 65.89% ( 6 192 cases ) were at ages of <60 years, and 92.35% ( 8 678 cases ) were treatment-naïve. There were 1 425 patients with drug-induced liver injury (15.16% incidence), including 729 cases with grade 1 (51.16%), 24 cases with grade 2 (1.68%), 7 cases with grade 3 (0.49%), 7 cases with grade 4 ( 0.49% ), and 658 cases with ungraded drug-induced liver injury ( 46.18% ). The median duration between drug administration and development of drug-induced liver injury was 24 ( interquartile range, 44 ) days. Multivariable logistic regression analysis identified treatment-naïve ( OR=1.464, 95%CI: 1.153-1.859 ) and history of liver disease ( OR=2.001, 95%CI: 1.709-2.342) as risk factors for drug-induced liver injury in patients with pulmonary tuberculosis.@*Conclusion@#The incidence of drug-induced liver injury was 15.16% among pulmonary tuberculosis patients in Ningbo City from 2015 to 2019. Treatment-naïve and a history of liver disease are associated with drug-induced liver injury among patients with pulmonary tuberculosis.

Spatio-temporal clustering analysis of pulmonary tuberculosis in Ningbo City from 2015 to 2020 / 预防医学

Objective@#To investigate the spatio-temporal distribution characteristics of pulmonary tuberculosis in Ningbo City from 2015 to 2020, so as to provide insights into tuberculosis control.@*Methods@#The data of pulmonary tuberculosis cases in Ningbo City from 2015 to 2020 were collected from Tuberculosis Management Information System of China Disease Control and Prevention Information System, and were linked with the geographic information database of Ningbo Planning Design and Research Institute. The software SaTScan version 10.3 was employed for monthly spatio-temporal scanning and cluster analysis of reported pulmonary tuberculosis cases, populations, longitude and latitude in 153 townships of Ningbo City from 2015 to 2020. @*Results@#There were one class Ⅰ cluster and two class Ⅱ clusters of pulmonary tuberculosis cases in Ningbo City from 2015 to 2020, and the class Ⅰ cluster was centered in Song'ao Township and covered 37 townships, with aggregation time from January 1, 2015 to December 31, 2017, while class Ⅱ clusters were covered 38 tounships which were centered in Sanqishi Township of Yuyao County, and one township in Hangzhou Bay New Town. The aggregation time was from January to June in 2015 and 2016, from March to August between 2017 and 2019 and between May and October, 2020. The overall reported incidence of pulmonary tuberculosis appeared a tendency towards a decline in each township of Ningbo City from 2015 to 2020; however, the incidence of pulmonary tuberculosis was more than 80 per 100 thousand in Fuming Township of Yinzhou District and Juexi Township of Xiangshan County in 2020.@*Conclusions@#There were significant spatio-temporal clustering characteristics of pulmonary tuberculosis incidence at a township level in Ningbo City from 2015 to 2020, and the clusters were mainly concentrated in the central and eastern Ningbo City. The reported incidence of pulmonary tuberculosis is high in Fuming Township of Yinzhou District and Juexi Township of Xiangshan County, where targeted regional tuberculosis control strategies should be implemented.

Second-line injectable drugs resistance-associated mutation among multi-drug resistant tuberculosis strains in Ningbo, China / 中国人兽共患病学报

We identified the Beijing family strains of multiple drug-resistant tuberculosis and find out the distribution of second-line injectable drugs resistance-associated nucleotide alteration among the MDR strains in Ningbo.The 106 MDR isolates were selected from the first drug resistant survey in Ningbo during 2014 and 2016.The conventional drug susceptibility testing was used to detect the drug-resistant profiles against 3 second-line injectable drugs (kanamycin,amikacin,capreomycin).The RD105 deletion-targeted multiplex PCR method was used to distinguish the genotype among 106 MDR strains.The gene mutations of second-line injectable drugs resistance-associated among MDR-TB strains were detected by direct DNA sequencing.Results showed that out of the 106 MDR isolates,83(78.3％,83/106) belonged to Beijing genotype,while the other 23(21.7％,23/106) were non-Beijing genotype.There were 10 strains with second-line injectable drugs resistance in 83 Beijing genotype MDR strains and there were no strains with second-line injectable drugs resistance in 23 non-Beijing genotype MDR strains.The Beijing MDR strains had significantly higher proportions of second-line injectable drugs resistance than non-Beijing strains.There were 4 with mutations in 10 MDR-TB with second-line injectable drugs resistance and there were 24 with mutations in 96 MDR-TB without second-line injectable drugs resistance (x2=1.048,P＞0.05).Beijing genotype MDR strains revealed a significant association with second-line injectable drugs resistance.The mechanism of second-line injectable drugs resistance in MDR-TB is mainly in no connection with the mutation of the genes.

Da Vinci robot assisted radical gastrectomy with carbon nanoparticle lymph node dyeing for advanced gastric cancer / 中华普通外科杂志

Objective To investigate the application value of carbon nanoparticle lymphatic tracer in Da Vinci robot-assisted radical gastrectomy for advanced gastric cancer.Methods The clinical data of 63 advanced gastric cancer patients in Gansu Provincal Hospital in 2016 were analyzed retrospectively.Patients were divided into three groups:robot with carbon nanoparticle group,laprascopy with carbon nanoparticle group and laprascopy surgury group.Numbers of harvested lymph were compared between the 3 groups,and the perioperative complications were evaluated.Results The number of harvested lymph nodes in carbon nanoparticle group (31.5 ± 3.8) was significantly higher than those of laprascopy joint carbon nanoparticle group (25.3 ± 2.6),F =5.5,P =0.03 and laprascopy group (21.1 ± 2.7),F =6.1,P=0.01.The number of blackdyed harvested lymph node was 481 (76.2％) and the metastasis rate of black-dyed lymph node was 26.8％ in robot joint carbon nanoparticle group.There was no significant difference in the metastasis rate of black-dyed between the robot joint carbon nanoparticle group and laprascopy joint carbon nanoparticle group,x2 =0.17,P =0.22.Condusions The application of diluted carbon nanoparticle lymphatic tracer helps in the dissection of lymph nodes in Da Vinci robot-assisted radical gastrectomy for advanced gastric cancer.

Trends and impact factors of drug-resistant tuberculosis in Ningbo from 2007 to 2010 / 中华传染病杂志

Objective To determine the prevalence,trends and risk factors of drug-resistant tuberculosis (TB) in Ningbo during 2007-2010,and to explore the efficient control strategy of drugresistant TB.Methods A cross-sectional study of regional anti-TB drug resistance was conducted in Ningbo.The registered and culture-positive TB patients were enrolled and drug sensitivity test was performed.The demographic and clinical information were collected from the national TB report system.Logistic regression model was used to determine the risk factors of drug resistance.Results Of 1613 enrolled TB patients,39.3％-48.3％ were resistant to any first-line anti-TB drug and 14.0％-19.9％ were multidrug resistant (MDR)-TB.The proportion of new cases resistant to any first-line anti-TB drug was 35.4 ％-42.1％ and MDR TB was 9.8％- 12.2 ％,which were both significantly lower than those of retreated patients (69.5％-72.7％ and 33.9％ - 54.5％,respectively).The multivariate Logistic regression model showed that anti-TB treatment history and migration were significantly associated with any drug resistance (OR=3.298,95 ％ CI 2.391 4.550and OR=0.771,95 ％CI 0.608 - 0.978,respectively) ; while age,treatment history and migration were also significantly associated with MDR-TB.Conclusions Drug-resistant TB prevalence showed a decrease trend in Ningbo,while the resistant rates in both new cases and retreated cases still remain at high levels. Improved case management,including directly observed treatment short-course and appropriate treatment regimens specifically for drug-resistant TB,should be developed to prevent further transmission and development of drug-resistant TB in this setting.

Treatment of Facial Wrinkels with Char-Free Carbon Dioxide Laser and Erbium: YAG Laser / 대한피부과학회지

BACKGROUND: Laser facial skin resurfacing has become a method of treatment for photoaging and pigmentary conditions. Although excellent results can be obtained by high-energy, pulsed carbon dioxide(CO2) laser, significant morbidity exists due to the considerable thermal damage to the skin. The Erbium: Yttrium Aluminum Garnet(Er: YAG) laser, with a wavelength of 2940 nm, is well absorbed in water. This leads to a very small zone of thermal necrosis, compared ta the CO2 laser. OBJECTIVE: The purpose of this study was to evaluate the results of the combined use of the char-free CO2 laser and the Er: YAG laser in the treatment of facial wrinkles. METHODS: Forty-six patients, aged between 30 and 68 years, with facial wrinkles, were evaulated. Two types of resurfacing laser systems were utilized in this study, a high-energy, short-pulsed CO2 laser and a Er: YAG 1aser. Wrinkle improvement was evaulated by the patients satisfaction, clinical improvement, and photographic analysis before and after the resurfacing procedure. RESULTS: Twenty-six of the 46 patients had greater than an 80% improvement, and 19 patients had a 60-80% improvement. Only one patient showed a 50% or less improvement. CONCLUSIONS: The combination of char-free CO2 laser and Er: YAG laser for facial wrinkles is a safe and effective modality for laser skin resurfacing.

Clinical Study on Skin Disorders in Aged Persons / 대한피부과학회지

This statistical analysis was made out of 2,259 clinical cases (9. 9%) of akin disorders in the aged group over 50 years of age, among from the total 22,931 cases of outpatients, from 1974 to 1978, at Department of Dermatology, Sung-Sim HospitaI. Sex difference of the patients-male, 1, 057 (46. 8%), female, 1, 202 (53. 2%)-was found statistically significant. (countinued...)

A Case of Letterer - Siwe Disease / 대한피부과학회지

Letterer-Siwe disease in an acutely onset, progressive and fatal disorder of RES, usually appears in male children, chareacterized by constitutional signs and extraos-seous lesions. This case occurred in a 18-day-old female showing hepatomegaly, hemorrhagic crusted papular eruptions on the entire body, and abdominal distension. Direct smear of scraping materials from the skin lesion showed numerous histiocytes. Hematologic and other laboratory examinatons showed no abonormalities.