Assessment of the Caries Detection Ability of Quantitative Light-induced Fluorescence (QLF) in Primary Teeth in vitro / 대한소아치과학회지

The aim of this study was to evaluate QLF (quantitative light-induced fluorescence) technology for the caries detection in primary teeth and validate the relationships between the cavity volume of carious lesions and QLF analysis results. Total 125 tooth surfaces include 53 occlusal surfaces, and 72 proximal surfaces were investigated with the portable QLF device for detection of dental caries in primary molars. Micro-CT radiograph was also performed to classify carious lesions and calculate the cavity volume. QLF showed good accuracy and reliability (sensitivity 0.75 - 0.94, specificity 0.82 - 0.95, and AUROC 0.88 - 0.98) for the caries detection in primary teeth except ΔR average results of proximal caries which showed relatively low values. Statistically significant relationships were found between ΔF average, QS-Index and the cavity volume according to Spearman rank-order correlation coefficients (r = 0.805 - 0.832, p < 0.001). QLF detection method would be a harmless and reliable way for children to diagnose dental caries without the concern about radiation exposure.

A Case of Xanthogranulomatous Pyelonephritis with Nephropleural Fistula Formation: Role of MRI in Diagnosis and Treatment

Xanthogranulomatous pyelonephritis (XGP) is a rare type of chronic bacterial nephritis, which rarely involves the invasion of adjacent organs or the formation of fistulas due to tissue-destructive granulomatous reactions. Although the invasions of various adjacent organs have been reported in several cases of XGP, MRI data on their features are limited. MRI has a better soft-tissue resolution than CT. Thus, it can identify the extent of extrarenal involvement in advanced XGP, and the findings can be used in treatment planning. Herein, we report a rare case of XGP with nephropleural fistula formation diagnosed using CT and MRI.

A Case of Xanthogranulomatous Pyelonephritis with Nephropleural Fistula Formation: Role of MRI in Diagnosis and Treatment

Xanthogranulomatous pyelonephritis (XGP) is a rare type of chronic bacterial nephritis, which rarely involves the invasion of adjacent organs or the formation of fistulas due to tissue-destructive granulomatous reactions. Although the invasions of various adjacent organs have been reported in several cases of XGP, MRI data on their features are limited. MRI has a better soft-tissue resolution than CT. Thus, it can identify the extent of extrarenal involvement in advanced XGP, and the findings can be used in treatment planning. Herein, we report a rare case of XGP with nephropleural fistula formation diagnosed using CT and MRI.

Skin Barrier Dysfunction in the Scalp, Nails, and Lips in Patients with Atopic Dermatitis / 대한피부과학회지

Background@#Atopic dermatitis is a chronic, inflammatory disease affecting the skin including the scalp, nails, and lips. One of the main pathogenesis of atopic dermatitis is skin barrier impairment. Transepidermal water loss is a noninvasive measurement of water loss across the stratum corneum for assessing skin barrier function. @*Objective@#This study aimed to evaluate the skin barrier function of various skin sites including hairy skin, non-keratinized areas, and hard keratin in patients with atopic dermatitis. Furthermore, the relationship between the severity of atopic dermatitis and transepidermal water loss was investigated. @*Methods@#In total, 73 patients with atopic dermatitis and 65 age-matched healthy controls were included in this study. Transepidermal water loss was measured at 8 different skin sites including hairy skin (vertex, occiput), the cheek, non-keratinized area (lower lip), lateral side of the upper arm, flexor side of the forearm, extensor side of the forearm, and hard keratin (fingernail). The severity of atopic dermatitis was assessed using the eczema area and severity index. @*Results@#Transepidermal water loss was observed to be higher at all the measured sites including the scalp, nails, and lips of atopic dermatitis patients in comparison with that of the age-matched controls. Transepidermal water loss were correlated with the severity of atopic dermatitis in the cheek, lips, upper arm, and forearm. @*Conclusion@#Patients with atopic dermatitis have impaired skin barrier function, including in regions of hairy skin, non-keratinized areas, and hard keratin areas. Barrier dysfunction is associated with the severity of atopic dermatitis.

Basal Cell Carcinoma Arising within Seborrheic Keratosis

No abstract available.

Treatment Results of a Periprosthetic Femoral Fracture Case Series: Treatment Method for Vancouver Type B2 Fractures Can Be Customized

BACKGROUND: Currently, an algorithmic approach for deciding treatment options according to the Vancouver classification is widely used for treatment of periprosthetic femoral fractures after hip arthroplasty. However, this treatment algorithm based on the Vancouver classification lacks consideration of patient physiology and surgeon's experience (judgment), which are also important for deciding treatment options. The purpose of this study was to assess the treatment results and discuss the treatment options using a case series. METHODS: Eighteen consecutive cases with periprosthetic femoral fractures after total hip arthroplasty and hemiarthroplasty were retrospectively reviewed. A locking compression plate system was used for osteosynthesis during the study period. The fracture type was determined by the Vancouver classification. The treatment algorithm based on the Vancouver classification was generally applied, but was modified in some cases according to the surgeon's judgment. The reasons for modification of the treatment algorithm were investigated. Mobility status, ambulatory status, and social status were assessed before the fracture and at the latest follow-up. Radiological results including bony union and stem stability were also evaluated. RESULTS: Thirteen cases were treated by osteosynthesis, two by revision arthroplasty and three by conservative treatment. Four cases of type B2 fractures with a loose stem, in which revision arthroplasty is recommended according to the Vancouver classification, were treated by other options. Of these, three were treated by osteosynthesis and one was treated conservatively. The reasons why the three cases were treated by osteosynthesis were technical difficulty associated with performance of revision arthroplasty owing to severe central migration of an Austin-Moore implant in one case and subsequent severe hip contracture and low activity in two cases. The reasons for the conservative treatment in the remaining case were low activity, low-grade pain, previous wiring around the fracture and light weight. All patients obtained primary bony union and almost fully regained their prior activities. CONCLUSIONS: We suggest reaching a decision regarding treatment methods of periprosthetic femoral fractures by following the algorithmic approach of the Vancouver classification in addition to the assessment of each patient's hip joint pathology, physical status and activity, especially for type B2 fractures. The customized treatments demonstrated favorable overall results.

Neuroprotective effects of geneticin (G418) via apoptosis in perinatal hypoxic-ischemic brain injury / 소아과

PURPOSE: Some antibiotics were known to exert neuroprotective effects in the animal model of hypoxic-ischemic (H-I) brain injury, but the mechanism is still unclear. A recent study reported that geneticin (G418), an aminoglycoside antibiotic, increased survival of human breast cancer cells by suppressing apoptosis. We investigated the neuroprotective effects of systemically administrated geneticin via anti-apoptosis following the H-I brain injury METHODS: Seven-day-old Sprague-Dawley rat pups were subjected to unilateral (left) common carotid artery occlusion followed by 2.5 hours of hypoxic exposure and the cortical cell culture of rat brain was done under a hypoxic incubator. Apoptosis was measured in the injured hemispheres 7 days after H-I insult and in the injured cells from hypoxic chamber using morphologic analysis by Terminal dUTP Nick-end Labeling(TUNEL) assay and immunohistochemistry for caspase-3, and cytologic analysis by western blot and real time PCR for bax, bcl-2, and caspase-3. RESULTS: The gross appearance and hematoxylin and eosin stain revealed increased brain volume in the geneticin-treated animal model of perinatal H-I brain injury. The TUNEL assay revealed decreased apoptotic cells after administration of geneticin in the cell culture model of anoxia. Immunohistochemistry showed decreased caspase-3 expression in geneticin-treated cortical cell culture. Western blot and real-time PCR showed decreased caspase-3 expression and decreased ratio of Bax/Bcl-2 expression in geneticin-treated animal model. CONCLUSION: Geneticin appears to exert a neuroprotective effect against perinatal H-I brain injury at least via anti-apoptosis. However, more experiments are needed in order to demonstrate the usefulness of geneticin as a preventive and rescue treatment for H-I brain injuries of neonatal brain.

DNA Microarray Analysis of Gene Expression Profiles in Aging process of Mouse Brain

In order to investigate the molecular basis of the aging process in brain, we have employed high-density oligonucleotide microarrays providing data on 10,108 gene clusters to define transcriptional patterns in three brain regions, cerebral cortex, cerebellum, and hippocampus. Comparison of the expression patterns between young (6-week-old) and aged (17-month-old) C57BL/6 male micerevealed that about ten percent (1098) of the genes showed a significant change in the expression level in at least one of the three tissues. Among them, 23 genes were upregulated and 62 genes were downregulated in all three tissues of the old mice. The number of genes upregulated exclusively in hippocampus (337) was much larger compared to other tissues. Gene ontology-based analysis showed the genes related with signal transduction or molecular transports are more likely to be upregulated than downregulated in the aging process of hippocampus. These data may provide some useful means for elucidating the molecular aspect of aging in hippocampus and other regions in brain.

Successive Suture Device for Gastrointestinal Endoscopes / 대한소화기내시경학회지

BACKGROUND/AIMS: Recently, treatment using an endoscopic device is actively being developed. Techniques for incision and bleeding control have been developed, but endoscopic suturing remains to be perfected. Using an endoscopic suturing technique, a variety of diseases could be managed noninvasively. We have attempted to use a new endoscopic suturing device which enables a continuous suture using a flexible upper endoscope. METHODS: A suturing device was designed where a semicircular needle could sew through tissue by rotation making a continuous suture possible. RESULTS: We successfully sutured the stomach tissue of a dog using an optimized suturing device model. CONCLUSIONS: The initial model was found to have some problems. However, we hope to develop a continuous suturing device for flexible upper endoscope procedures in Korea.

Open-Approach Rhinoplasty with Use of Extended Incision

The purpose of this study was to introduce an extended incision in open-approach rhinoplasty for obtaining greater satisfaction in aesthetic rhinoplasty. This incision was similar with the usual open rhinoplasty incision but it is extended along the caudal border of the footplates of the medial crura onto the floor of the nasal vestibule in order to access the footplates of the medial crura more easily. This simple extended incision enabled us to achieve further tip projection because the pressure of the skin flap on the tip was reduced. In addition, a cartilage graft or an implant insertion for alar base augmentation could be performed through this extended incision without an additional incision. Another advantage was that in correction of caudal septal deviation, displaced septal cartilage could be repositioned by suturing to the periosteum or soft tissue around the anterior nasal spine without drilling into it through intraoral incision. Fifty-one consecutive patients who underwent our extended open-approach rhinoplasty between August of 1999 and September of 2000 were included in this study. A total of 40 patients had an adequate follow-up time of over 6 months. The majority of the patients(35/40 cases) were satisfied with the results of the procedure. Two patients had complications of nostril scar contracture requiring close follow-up. There were no cases of implant extrusion, displacement, or infection. Nor did any patients experience transcolumellar or extended incision scarring.

Second Toe Medial Plantar Free Flap for the Pulp Reconstruction of Fingertip

The aim of this study is to report usefulness and postoperative results of the second toe medial plantar free flap for fingertip reconstruction. From July 1997 to December 1999, 17 fingers of 17 patients with pulp defect of fingers were reconstructed by second toe medial plantar free flaps. The artery and nerve of the flap is obtained from the second toe medial plantar neurovascular bundle. Venous flow is obtained from dorsal vein. The donor site was closed with a full-thickness skin graft. The survival of these flaps was successful in all cases. All procedures were performed by the two-team approach. Average flap size was 2 X 2.5 cm. The follow-up period ranged from 2 months to 29 months. The mean value of moving and static 2 point discrimination test in 14 cases were 4.4 and 6.2 mm, respectively. We have obtained satisfactory sensory restoration and aesthetic appearance. No functional deficit was found at the donor site. We reviewed the medical records of our cases and analyzed them in several aspects. The major advantage of this flap is to provide aesthetic improvement of the recipient and donor site. We also modified the incision line of the second toe by including the medial portion of the flap, which is easier to dissect and enables neurovascular pedicles to be dissected in one operative field. We conclude that this surgical method is a safe and reliable procedure with a high successful rate for reconstruction of fingertip injury, especially for the pulp defect.

Second Toe Medial Plantar Free Flap for the Pulp Reconstruction of Fingertip

The aim of this study is to report usefulness and postoperative results of the second toe medial plantar free flap for fingertip reconstruction. From July 1997 to December 1999, 17 fingers of 17 patients with pulp defect of fingers were reconstructed by second toe medial plantar free flaps. The artery and nerve of the flap is obtained from the second toe medial plantar neurovascular bundle. Venous flow is obtained from dorsal vein. The donor site was closed with a full-thickness skin graft. The survival of these flaps was successful in all cases. All procedures were performed by the two-team approach. Average flap size was 2 X 2.5 cm. The follow-up period ranged from 2 months to 29 months. The mean value of moving and static 2 point discrimination test in 14 cases were 4.4 and 6.2 mm, respectively. We have obtained satisfactory sensory restoration and aesthetic appearance. No functional deficit was found at the donor site. We reviewed the medical records of our cases and analyzed them in several aspects. The major advantage of this flap is to provide aesthetic improvement of the recipient and donor site. We also modified the incision line of the second toe by including the medial portion of the flap, which is easier to dissect and enables neurovascular pedicles to be dissected in one operative field. We conclude that this surgical method is a safe and reliable procedure with a high successful rate for reconstruction of fingertip injury, especially for the pulp defect.

Cavernous Sinus Lesions Treated in Otorhinolaryngology-Head and Neck Surgery Field / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Cavernous sinus is a small venous space enclosed by leaves of dura and periosteum and located on either side of sella turcica. Approach and treatment of lesions of this sinus are very difficult and perilous because they contain critical neural and vascular structures. Surgery relating to cavernous sinus lesions are extremely rare in otorhinolaryngology and such surgeries are usually referred to the fields of neurology and neurosurgery. However, in the case of a lesion that extends from the nasal cavity and the paranasal sinuses, an intranasal approach is necessary and cooperation with head and neck surgeons are desirable to achieve a superior result. This study examines the nature of these rare cases of cavernous sinus lesions and assesses the results of cooperation with doctors of other specialties. MATERIALS AND METHODS: We summarize here three cases of cavernous sinus lesions (angiofibroma, tuberculosis, foreign body) extendeding from the nasal cavity and paranasal sinuses. These lesions were treated in cooperation with a reconstructive surgeon and a neurosurgeon. RESULT: All of these cases showed successful results. CONCLUSION: Close cooperation from each department is critical in order to achieve successful results.

Expression Correlation Between NM23/NDP Kinase and c-myc in NM23/NDP Kinase Transfectant Cell Lines / 체질인류학회지

Since Steeg, et al.(1988) identified NM23/NDP kinase as non -metastasis gene, other multiple functions of have reported. One of them, Postel, et al.(1993) suggested that transcription factor PuF, being encoded by NM23 -H2/NDP kinase gene, interacts with nuclease hypersensitive element located upstream of the c -myc gene. C -myc amplification and activation can be present in squamous cell carcinoma of the head and neck as well as in an increased metastatic propensity for individual tumor. To clarify the role of NM23/NDP kinase on c -myc expression, comparison of these two gene expressions in cell lines was done. No direct correlation of expression kinetics was found. A plasmid containing human c -myc fragment was cloned upstream of chloramphenicol acetyltransferase (CAT) gene. When murine melanoma cell line was cotransfected with a murine NM23 -M2 including expression vector and c -myc CAT, CAT activity was elevated, while no change of CAT activity was found in the cotransfectant of human NM23 -H2 and c -myc CAT. Data suggest that murine NM23 -M2 gene transactivates c -myc gene indirectly with a cellular factor in murine cell line which dose not work with human NM23 -H2 gene. Additionally, we found same kinetics of NM23 -H2/NDP kinase and c -myc expression change correlated with proliferation of PLC/PRF/5 which was induced by HGF.

Treatment of Posterior Epistaxis with Posterior Endoscopic Laser Photocoagulation / 대한이비인후과학회지

Epistaxis is a common otolaryngologic emergency. Posterior epitaxis is more frequent in the elderly and associates with hypertension and arteriosclerosis. This is apt to be more vigorous in volume, is more difficult to identify the active bleeding point, and is more troublesome to contol. A number of different treatments are used to control the posterior epistaxis. Some of these are deep anterior packing, posterior packing, nasal balloon tamponade, arterial ligation, arterial embolization and posterior endoscopic cautery. Recently we directly photocoagulated the bleeding points in 7 cases of posterior epistaxis using endoscope and KTP/532 laser. The epistaxis was controlled in all cases without any significant complication.

Symptom Relief after Endoscopic Sinus Surgery:A Prospective Analysis / 대한이비인후과학회지

Chronic paranasal sinusitis is one of the most common disease in the field of otolaryngology, and endoscopic sinus surgery(ESS) is efficient and safe operative method of chronic paranasal sinusitis. We employed socalled symptom score to quantify the common sinusitis related symptoms before and after endoscopic sinus surgery which followed up to 6 months. A prospective study of 50 patients all having undergone ESS from June, 1995 to February, 1996 was performed and we analyzed the surgical results using questionaires which focused on six common sinusitis related symptoms-nasal obstruction, rhinorrhea, olfactory disturbance, postnasal drip, headache and sneezing. Postoperative symptom relief was apparent in all six common symptoms(p value<0.001) and the higher sinusitis stage, the more relief of sinusitis related symptoms(p value=0.029). It seems to be helpful to employ a symptom score in predicting and analyzing the surgical results in the treatment of chronic sinusitis.

Laparoscopic common bile duct exploration(LCBDE)

No abstract available.

A case of typhoid fever complicated by complete AV block, myocarditis and pancreatitis / 감염

No abstract available.

A case of meningoencephalitis due to streptococcus pneumoniae in a patients with chronic graft-versus-host disease after allogeneic bone marrow transplantation / 감염

No abstract available.

A case of meningoencephalitis due to streptococcus pneumoniae in a patients with chronic graft-versus-host disease after allogeneic bone marrow transplantation / 감염

No abstract available.