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Journal of Experimental Hematology ; (6): 1424-1428, 2021.
Artigo em Chinês | WPRIM | ID: wpr-922275

RESUMO

OBJECTIVE@#To investigate the relationship between hypoxia inducible factor 1 (HIF1α) and Wilms' tumor 1associating protein (WTAP) expression level in t(8;21) acute myeloid leukemia cells.@*METHODS@#The t(8;21) acute myeloid leukemia cell lines, including SKNO-1 and Kasumi-1 were treated by Echinomycin for 24 h, RT-qPCR and Western blot were used to detect the expression levels of WTAP mRNA and the protein. The CoCl @*RESULTS@#The expression level of WTAP mRNA and the protein in the echinomycin treated group was significantly lower than those in the control group (P<0.01). The expression level of WTAP protein in the CoCl@*CONCLUSION@#The inhibition of HIF1-α could down-regulates the expression of WTAP, while the up-regulation of HIF1α could up-regulates the expression of WTAP, which shows that there is a positive correlation of HIF1α and WTAP expression. This result suggesting that HIF1α may be involves in the expression regulation of WTAP gene.


Assuntos
Humanos , Proteínas de Ciclo Celular , Subunidade alfa do Fator 1 Induzível por Hipóxia , Leucemia Mieloide Aguda/genética , Proteínas Nucleares , Fatores de Processamento de RNA , RNA Mensageiro
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