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OBJECTIVE:To compare the therapeutic efficacy and safety of olanzapine and risperidone in the treatment of cognitive function in schizophrenia patients.METHODS:The information of 98 patients with schizophrenia were analyzed retrospectively and divided into control group and observation group according to therapy method,with 49 cases in each group.The patients receiving antipsychotic drugs were included in study after 7 d of drug withdrawal and cleaning.Control group received Risperidone tablet with initial dose of 1 mg,twice a day,orally,increasing to 4-6 mg within a week,twice a day,for consecutive 6 months.Observation group was given Olanzapine tablet with initial dose of 5 rag,twice a day,orally,increasing to 15-20 mg within a week,twice a day,for consecutive 6 months.Clinical efficacies of 2 groups were observed,and PANSS,WMS score (MQ score),TMT score (TMT-A connection time,TMT-A error number,TMT-B connection time,TMT-B error number score),WCST score (the number of completion classification,the number of sustained response,total number of errors,the number of persistent error and total correct number) were observed before and after treatment.The occurrence of ADR was recorded.RESULTS:There was no statistical significance in total response rate between 2 groups (93.88％ vs.97.96％,P＞0.05).After treatment,PANSS score,TMT-A connection time,TMT-A error number,TMT-B connection time,TMT-B error number,sustained response number,total error number and persistent error number scores in 2 groups were significantly lower than before treatment;PANSS score of observation group was significantly lower than that of control group;there was no statistical significance in other indexes betwee 2 groups.MQ score,the number of completion classification and total correct number score of 2 groups were significantly higher than before treatment,with statistical significance (P＜0.05 or P＜0.01);but there was no statistical significance between 2 groups(P＞0.05).The incidence of weight gain and lethargy in observation group was significantly higher than control group,and the incidence of extrapyramidal reaction,insomnia,headache,dizziness and dry mouth were significantly lower than control group,with statistical significance (P＜0.05).CONCLUSIONS:Therapeutic efficacy of olanzapine is similar to that of risperidone in the treatment of schizophrenia.Both of them can effectively improve cognitive function.Olanzapine is better than risperidone in improving psychiatric symptoms,but it increases the incidence of body weight gain and lethargy.
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Objective To study the occurrence of anxiety in patients with malignant tumor, and in further explore the scientificity and clinical application value of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI) technology in anxiety detection. Methods 1 000 patients with malignant tumor were selected as research objects, the self-rating anxiety scale (SAS) was used to evaluate the anxiety on the first day of admission, the fasting venous blood of patients was taken on the next day morning. The SAS score and SELDI result were compared and analyzed. Results The effective sample number was 988. The SAS score was 56.32± 9.665, there were 454 cases of anxiety, the incidence rate of anxiety was 45.95 %. 470 cases were SELDI test positive, and the incidence rate of anxiety was 47.57 %. SAS was used as the gold standard to judge anxiety, the sensitivity and specificity of SELDI technology were 93.17 % and 91.20 %, the positive predictive value and negative predictive value were 90.00 % and 94.02 %, the total coincidence rate was 92.11 %. SAS score highly correlated with the abundance of SELDI, the fitting curve showed an up trend, and the correlation coefficient was 0.837. Conclusions The incidence of malignant tumor patients ' anxiety is relatively high. SELDI technique shows high sensitivity, specificity, total coincidence rate and correlation in anxiety detection, it can be used as an objective evaluation of anxiety.
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Objective To investigate the incidence of anxiety in patients with breast cancer,and further explore the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI) technology' s clinical value in the diagnosis of anxiety.Methods 121 breast cancer patients were selected as research objects by using convenience sampling method.Self-rating anxiety scale (SAS) was used to evaluate the anxiety on the first day of admission and SELDI was used on the next day to detect the serum from patients' fasting venous blood sample got in the morning after their consent,then anxiety-related protein fingerprints spectrums were selected.The SAS score and SELDI result were finally compared and analyzed.Results SAS score in 121 patients was 53.45±9.78,anxiety occurred in 63 cases (52.07 ％).Established the diagnostic model between 15 000+H and 16 800+H protein fingerprints abundance ≥5 ％,that was to say,abundance ≥5 ％ was judged as positive,otherwise negative.On this basis,patients can accurately be distinguished between anxious group and non-anxious group.Correct rate (total coincidence rate) was 91.74 ％,specificity and sensitivity respectively were 89.66 ％ (52/58) and 93.65 ％ (59/63),the positive predictive value was 90.77 ％ (59/65),and negative predictive value was 92.86 ％ (52/56).Conclusions Breast cancer patients have a high incidence of anxiety.SELDI technology has showed high sensitivity and specificity in anxiety detecting.As an objective assessment tool,it could have better prospects for clinical use.