RESUMO
Objective To understand the freshmen’s status of hepatitis B virus infection,immunological effect after vaccina-tion against hepatitis B from a university in Ankang city,to provide a scientific basis for university’s prevention from hepati-tis B.Methods Analyzed the results of five markers of hepatitis B virus infection and alanine aminotransferase (ALT)of 25 895 freshmen in a college in Ankang for resent 12 years,and observed the HBsAb serocoversion in serum 1 year after vacci-nation against hepatitis B and after strengthened immunity.Results The HBeAg positive rate of the freshmen was 4.07%, among which the male was 5.58% (281/5 035),and the female was 3.14% (258/8 214).The difference had significance of statistic (P<0.05).The college students’HBeAg positive rate from rural area and from urban area were 4.77% and 2.93%respectively,the difference had significance of statistic (P<0.05).There was no significant statistic difference in immune effect of hepatitis B vaccine for different sex (χ2=5.80,P<0.05).Their HBsAb positive rate was 95.15% after injected with 10μg hepatitis B and 5μg hepatitis B vaccine,which had significance of statistic (P<0.05).Conclusion The hepatitis B virus infection rate and the hepatitis B protective antibody of the college freshmen in Ankang district was lower than that of the whole country and had a decreased tendency.It showed the male’s infection rate of hepatitis B virus was higher than the female,the rural was higher than the urban,and the immune effect of hepatitis B vaccine proved to be good.It should be-strengthened immunity for non-responders to ensure the immune effect if necessary.