Clinical observation of blood serum bilirubin level and the degree of coronary artery narrowing / 西安交通大学学报(医学版)

Objective To observe the relationship of blood serum bilirubin level with coronary heart disease and the degree of coronary artery narrowing. Methods A total of 126 patients were divided into the coronary disease group (83) and the control group (43). According to the coronary artery narrowing integral, the 83 patients in the coronary disease group were divided into three subgroups: mild narrowing group (15 people), moderate narrowing group (35 people), and severe narrowing group (33 people). The coronary arteriography of the patients in the control group was normal. 5mL venous blood was drawn on empty stomach, and the enzyme method was used to determine glycerin, the total cholesterol, the low density lipoprotein cholesterol, the high density lipoprotein cholesterol, and the blood serum bilirubin. Results The blood serum total bilirubin in the coronary disease group was (12.30?3.84)?mol/L, direct bilirubin was (4.07?1.45)?mol/L, and indirect bilirubin was (8.23 ? 2.82 )?mol/L. The total bilirubin in the normal group was (14.59?4.37)?mol/L, direct bilirubin was (4.66 ? 1.55 )?mol/L, and indirect bilirubin was (9.93?3.33)?mol/L. The total bilirubin, indirect bilirubin and direct bilirubin were lower in coronary disease group than in normal group (P0.05). Conclusion The blood serum bilirubin level and coronary disease have remarkable negative correlation, and the blood serum bilirubin level of patients with coronary disease is lower than that of healthy people. ② The blood serum bilirubin level and the degree of coronary artery narrowing do not have remarkable correlation.

PREVENTING RESTENOSIS FOLLOWING PTCA / 药物分析学报

Whether InfusaSleeve(IS) catheter can deliver antisense oligodeoxynucleotide (ODNs) following arterial denuation is unknown. We evaluate the feasibility of local endoluminal delivery of C-myc ODNs to the site of arterial denudation by using IS catheter and to determine the biological importance of these effects. IS catheter was introduced into right side of iliac artery of 21 rabbits after angioplasty of iliac artery. Animals were randomized to the control group (n＝6) receiving saline injection and the treated group receiving c-myc antisense (n＝15, 1 mg ODNs per vessel). In two weeks and 40 days following the operation, angiography was performed. Morphometric analyses were carried out in balloon-denuded iliac arteries. The expression of c-myc protein was detected by using a mouse monoclonal antibody to c-myc. Morphometric analyses carried out at 40 days after transcatheter c-myc antisense oligomer administration. The results showed that maximal neointimal area was reduced from 7.66±3.7(×105 μm2) in the control group (n＝6) to 4.04±1.02(×105 μm2) in the antisense treated group (n＝6, P＜0.05). These changes in vascular remodeling following denuding injury resulted in an increase in residual luman from 20～50% in the control group to 70～90% in the antisense-treated group. C-myc protein expression was virtually undetectable at baseline in locally ODNs-delivered arteries and detectable in control denuded arteries. The results show that: ①Single IS transcatheter administration allowed endoluminal delivery of ODNs to the site of arterial injury; ② c-myc antisense oligomer reduced the formation of neointime in denuded arteries, implying a therapeutic potential of this approach.