Application of appreciative intervention in humanistic nursing of patients undergoing renal biopsy / 中国实用护理杂志

Objective To explore the effect of appreciation intervention on anxiety and complications in patients with renal biopsy. Methods A total of 197 cases of renal biopsy patients were divided into the control group (n=96) and the observation group (n=101). The observation group was given comprehensive nursing intervention with appreciation, the control group was only given comprehensive nursing care, the two groups were evaluated with Zung Self-rating Anxiety Scale (SAS) upon admission and 1 week after puncture. Results After intervention, the SAS score of the observation group was 30.87 ± 4.52, and the SAS score of the control group was 32.32 ± 3.72, and the difference between the two groups was statistically significant (t=2.45,P<0.05). Totally 97 patients in the observation group and 78 cases in the control group received bed urination exercises, and the difference between the two groups was statistically significant (χ2=9.412,P<0.01). The complications of two groups were collected, the complications in the observation group were 27 cases, and the complications in the control group were 50 cases, the difference between the two groups was statistically significant (χ2=13.285,P<0.01). Among the postoperative complications, 8 of the patients in the observation group had urinary retention, and 19 of the control group had urinary retention (t=2.446,P=0.015). In the observation group, 3 cases had abdominal distention, and 10 cases in the control group suffered from abdominal distension (t=2.117, P=0.035). In the observation group, 1 case had low back pain, and 6 cases in the control group suffered from lumbago (t=2.004, P=0.047); the difference was statistically significant. Conclusions Appreciate intervention for patients with renal puncture biopsy has a positive impact on the bed urination exercise in puncture before surgery. It can alleviate the anxiety of patients received renal biopsy, reduce urinary retention, abdominal distension and pain complications, and improve bedridden experience.

Validation of the Chinese version of A Tool to Asses Quality of Life in Idiopathic Pulmonary Fibrosis in patients with interstitial lung disease / 中国实用护理杂志

Objective To evaluate the reliability and validity of the Chinese version of A Tool to Assess Quality of Life in Idiopathic Pulmonary Fibrosis (ATAQ-IPF), and discuss the applicability of this tool among interstitial lung disease (ILD) patients. Methods 128 patients with ILD were selected from the respiratory department of Peking Union Medical College Hospital, and a convenient sampling method was adopted. Test-retest reliability cofficient, Cronbach αinternal consistency, content validity, criterion related validity were used to evaluate the reliability and validity of the Chinese version of ATAQ-IPF. Results Among first 15 recruited patients, the localized ATAQ-IPF had good test-retest reliability, the intraclass correlation coefficient(ICC) calculation was 0.95 (P<0.05). The evaluation of all 128 patients showed excellent internal consistency with the Cronbach α was 0.96,Cronbach α values of each dimension were 0.60-0.93. The scale level content validity index (S-CVI) was 0.80;The item level content validity index (I-CVI)were 0.78-1.00,which proved good validity. The score between the Chinese version of ATAQ-IPF and St. George Respiratory Questionnaire(SGRQ) showed a significant correlation (r=0.69, P<0.01). Criterion related validity was good. 128 patients were grouped according to the entity and the degree of dyspnea,evaluated the quality of life. There was a significant difference between idiopathic pulmonary fibrosis (IPF) and non-IPF patients(t=2.99, P < 0.01).Also the differences between different degrees of dyspnea were statistically significant(t=16.05, P<0.01). Conclusions The Chinese version of ATAQ-IPF retains good reliability and validity, and is qualified to assess the quality of life among ILD patients.

Antitumor effect of phlomio1 in vivo and in vitro / 中国中药杂志

To study the antitumor effect of phlomiol extracted from Phlomis younghusbandii in vivo and in vitro. The inhibitory effect of phlomiol on two kinds of human tumor cells proliferation was assayed by MTT method. Transplant tumor models of S180 and H22 were used. After transplantation, different doses of phlomiol were given to the mice for 14 days. The inhibitory rates were calculated. MTT method was used to assess the proliferation of T spleen lymphocyte cells and the activity of NK cells in tumor-bearing mice with S180. Phlomiol (50-100 mg x L(-1)) inhibited the proliferation of three kinds of tumor cells in vitro, antitumor effect of phlomiol was in a dose-dependent manner (r = 0.989, P < 0.05). The inhibitory rates of phlomiol (2.5, 5, 10 mg x kg(-1)) were 28.5%-65.0% and 35.0%-74.5% in tumor-bearing mice with S180 and H22 respectively, It could stimulate the spleen T-cells in tumor-bearing mice with S180 and increase the activity of the NK cells. Phlomiol could inhibit the proliferation of three kinds of tumor cells in vitro, present antitumor effect on the tumor-bearing mice, and improve the immunological function.

The Meta Analysis on the Safety and Immunogenicity of Domestic and Imported Split Influenza Virus Vaccines / 中国疫苗和免疫

Objective To compare the safety and immunogenicity between domestic and imported,imported and imported split influenza virus vaccine in Chinese population. Methods The published studies during January 1996 and June 2008 on the comparison between split influenza virus vaccine were screened and evaluated.The meta analysis was performed on safety and immunogenicity using fixed model or random model according the heterogeneity of the studies. Results 12 studies which were all random controlled trials between split vaccine were included.10 trials were between domestic and imported vaccine,and 2 trials were between imported and imported vaccine.For 10 domestic and imported vaccine trials,the local reaction pooled OR=0.81,95% CI (0.59,1.11);the systemic reaction the pooled OR=0.78,95% CI (0.50,1.03);the H1N1 subtype seroconversion pooled OR= 0.94,95% CI (0.78,1.14);the H3N2 subtype seroconversion pooled OR =1.01,95% CI (0.87,1.17);the B type seroconversion total OR= 1.35,95% CI (0.98,1.85).For 2 imported and imported vaccine trials,the local reaction pooled OR = 1.19,95% CI (0.60,2.37);the systemic reaction the pooled OR =1.15,95% CI (0.71,1.87);the H1N1 subtype seroconversion pooled OR= 1.27,95% CI (0.37,4.37);the H3N2 subtype seroconversion pooled OR= 1.29,95% CI (0.39,4.33);the B type seroconversion pooled OR= 0.95,95% CI (0.46,1.37). Conclusions There were no statistical difference on the safety and immunogenicity between domestic and imported,imported and imported split influenza vaccine in Chinese population.

Influence of different location of implants on the stress distribution in mandibular implant-supported complete overdenture / 实用口腔医学杂志

Objective:To investigate the stress distribution of mandibular implant-supported complete overdenture and supporting tissue with different location of implants.Methods:By three-dimentional finite element method, the stress distribution in the supporting tissue and overdenture supported by implants located in the interforaminal region or bilateral canines and first molars area was analyzed.Results:The overdenture supported by implants located in the interforaminal region showed poor oblique loading resistance, the peak value of stress in implant-bone interface was 2.4-9.2 times higher than that of vertial loading. Under vertical or oblique loading conditions, there was higher stress concentration in implants and base plates. The overdenture supported by implants located in bilateral canions and first molars area manifested better mechanical characteristic, the peak value of stress in supporting tissue was in the physiological range of bone.Conclusion:The location of implants in molar area can enhance the ability of overdenture to resist oblique loading, reduce the peak value of stress in implant-bone interface.