RESUMO
OBJECTIVE:To optimize the formulation of norcantharidin sustained-release tablet and investigate its in vitro release characteristics. METHODS: The tablet was prepared by using hydroxy-propyl methyl cellulose (HPMC) as the matrix material. The formulation of the tablet was optimized with the amount of HPMC (A),the amount of lactose (B),the concentration of ethanol (C) and the amount of ethanol (D) as factors and with the comprehensive scores of the in vitro release rate as index. Meanwhile,the in vitro release characteristics of the optimized tablets were investigated. RESULTS: The optimal formulation of the tablet was as follows: A=12 g,B=1.5 g,C=90%,D=10 mL. At 2,6 and 12 h the cumulative release rates of the tablet reached (30.63?1.03)%,(51.70?1.51)% and (89.25?1.04)%,respectively. The mechanism for the drug release was the joint action of diffusion and bulk erosion. CONCLUSION: The optimized norcantharidin sustained-release tablet is up to the expected sustained-release efficacy.
RESUMO
OBJECTIVE:To analyze the chemical components of the essential oil from Cnidium monnieri from Anhui versus Henan by GC-MS.METHODS:The essential oil was extracted from Cnidium monnieri by steam distillation;the chemical components of the essential oil were detected by GC-MS;the relative contents of the chemical components were computed using area normalization method.Peaks were separated by capillary GC-MS and their corresponding compounds were identified.RESULTS:36 chief components from Cnidium monnieri from Anhui and 45 from that from Henan were identified.28 components were noted in both.There was great difference between the two Cnidium monnieri.CONCLUSION:This study serves as a scientific basis for the further exploitation and utilization of Cnidium monnieri.