Effects of urapidil on cardiovascular responses to tracheal intubation / 中华麻醉学杂志

To observe the effects of urapidil on the cardiovascular responses to tracheal intubation, forty-six patients (ASA Ⅰ - Ⅱ) were randomly divided into group A (n=23) and group B(n=23). Anesthesia was induced with valium 0.2mg/kg, 2.5% thiopental sodium 5mg/kg and tracheal intubation was facilitated with succinylcholine 1.5mg/kg. Urapidil 0.5mg/kg was intravenously given immediately after administration of succinylcholine in group A. After intubation. SP, DP,MAP,HR and RPP increased by 6%,12%, 15%, 24% and 28% in group A and increased by 30%,37%,33%,48% and 95% in group B respectively. Compared correspondingly with those in group B, the values of the parameters mentioned above decreased significantly in 5 minutes after intuhation in group A(P