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Indian J Pediatr ; 2008 Feb; 75(2): 135-8
Artigo em Inglês | IMSEAR | ID: sea-83289

RESUMO

OBJECTIVE: To uncover the frequency and the spectrum of NPHS2 mutations in Egyptian children with non familial steroid-resistant nephrotic syndrome (SRNS). METHODS: Sixteen patients were screened by PCR-single-strand conformation polymorphism analysis of NPHS2 gene followed by direct sequencing. RESULTS: NPHS2 mutations were evident in four patients (25%) who were bearing four novel mutations including two frame shift mutations (R238fs and P45fs) and two missense mutations (I136L and F216Y). There were no phenotypic or histological characteristics of patients bearing NPHS2 mutations, apart from the earlier onset of the disease, compared to those who were not bearing mutations. CONCLUSION: NPHS2 mutations are prevalent in Egyptian children with non-familial SRNS and this may in part explain the less favorable prognosis reported in these patients.


Assuntos
Criança , Pré-Escolar , Estudos Transversais , Egito/epidemiologia , Mutação da Fase de Leitura , Marcadores Genéticos , Humanos , Lactente , Peptídeos e Proteínas de Sinalização Intracelular/sangue , Proteínas de Membrana/sangue , Mutação , Mutação de Sentido Incorreto , Síndrome Nefrótica/epidemiologia , Reação em Cadeia da Polimerase , Polimorfismo Conformacional de Fita Simples , Prevalência , Prognóstico
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