RESUMO
Serum levels of phosphohexose isomerase (PHI), aldolase (ALD) and hexokinase (HK) activities have been determined in 76 patients of carcinoma cervix, in search of proper diagnostic and prognostic parameters. All the three glycolytic enzyme levels studied were found to be significantly elevated in all the groups of malignancy and showed a relation to the clinical stage and tumor. Serum PHI levels were of best diagnostic significance even at an early stage of the disease. The enzyme levels correlated well with the prognosis of the disease.
Assuntos
Ensaios Enzimáticos Clínicos , Feminino , Frutose-Bifosfato Aldolase/sangue , Glucose-6-Fosfato Isomerase/sangue , Hexoquinase/sangue , Humanos , Prognóstico , Neoplasias do Colo do Útero/diagnósticoRESUMO
The serum phosphohexose isomerase (PHI), aldolase and hexokinase activities have been determined in 36 patients of carcinoma ovary with different clinical stages and in 25 healthy normal female subjects. The serum PHI and hexokinase levels were significantly elevated (P less than .001) in all the stages of malignancy while serum aldolase was significantly elevated only in stages III and IV of malignancy. The enzyme levels showed statistically significant response to therapy in stage II patients. The mean values in patients with progression of the disease were not significantly different.
Assuntos
Feminino , Frutose-Bifosfato Aldolase/sangue , Glucose-6-Fosfato Isomerase/sangue , Hexoquinase/sangue , Humanos , Estadiamento de Neoplasias , Neoplasias Ovarianas/enzimologiaRESUMO
The enzyme activities of Lactate dehydrogenase (LDH). prostate fluid LDH isoenzymes phosphohexose isomerase (PHI), Aldolase (ALD) and Hexokinase (HK) were determined in the sera of 77 samples of males. There were 12 cases of carcinoma prostate with metastases, 15 without metastases, 25 with benign prostatic hypertrophy and 25 nontumor. The enzyme activities of nontumor and benign group were statistically similar. The prostatic fluid LDH5/LDH1 ratio and PHI has been found to be the most sensitive parameter for detecting carcinoma prostate. Serial determinations of LDH, PHI, ALD and HK were found valuable for following the course of the disease during therapy.
Assuntos
Frutose-Bifosfato Aldolase/sangue , Glucose-6-Fosfato Isomerase/sangue , Hexoquinase/sangue , Humanos , Isoenzimas , L-Lactato Desidrogenase/sangue , Masculino , Próstata/enzimologia , Hiperplasia Prostática/enzimologia , Neoplasias da Próstata/enzimologiaAssuntos
Adulto , Idoso , Creatina Quinase/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/enzimologia , PrognósticoRESUMO
Serum aldolase and hexokinase levels were determined in 197 serum samples. There were 152 breast carcinoma cases comprising 26 of group I, 82 of group II and 44 of group III, 25 normal healthy female subjects and 20 benign. Activity of both the enzymes was normal in benign group but significantly higher activities were observed in advanced disease as compared to controls (P less than .001). The enzyme activity levels showed good correlation to the groups of the disease.