Retraction notice to “Effect of phentolamine on myocardial extracellular matrix of cardiac remodeling in rats” (Asian Pacific Journal of Tropical Medicine (2014) 7(8) (645–649) (S1995764514601085) (10.1016/S1995-7645(14)60108-5))

This article has been retracted at the request of the journal Editorial Office. The authors have plagiarized part of a paper that had already appeared in Chinese Journal of Arteriosclerosis 2014, 4, 362–366. Article id: 1007-3949 (2014) 22-04-0362-05. One of the conditions of submission of a paper for publication is that authors declare explicitly that their work is original and has not appeared in a publication elsewhere. Re-use of any data should be appropriately cited. As such this article represents an abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

RETRACTED: Effect of phentolamine on myocardial extracellular matrix of cardiac remodeling in rats

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).This article has been retracted at the request of the journal Editorial Office.The authors have plagiarized part of a paper that had already appeared in Chinese Journal of Arteriosclerosis 2014, 4, 362–366. article id: 1007–3949 (2014) 22-04-0362-05. One of the conditions of submission of a paper for publication is that authors declare explicitly that their work is original and has not appeared in a publication elsewhere. Re-use of any data should be appropriately cited. As such this article represents an abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

Resveratrol-induced augmentation of telomerase activity delays senescence of endothelial progenitor cells / 中华医学杂志(英文版)

<p><b>BACKGROUND</b>Previous studies have shown that resveratrol increases endothelial progenitor cell (EPC) numbers and functional activity. Increased EPC numbers and activity are associated with the inhibition of EPC senescence. In this study, we investigated the effect of resveratrol on the senescence of EPCs, leading to potentiation of cellular function.</p><p><b>METHODS</b>EPCs were isolated from human peripheral blood and identified immunocytochemically. EPCs were incubated with resveratrol (1, 10, and 50 µmol/L) or control for specified times. After in vitro cultivation, acidic β-galactosidase staining revealed the extent of senescence in the cells. To gain further insight into the underlying mechanism of the effect of resveratrol, we measured telomerase activity using a polymerase chain reaction (PCR)-enzyme-linked immunosorbent assay (ELISA) technique. Furthermore, we measured the expression of human telomerase reverse transcriptase (hTERT) and the phosphorylation of Akt by immunoblotting.</p><p><b>RESULTS</b>Resveratrol dose-dependently inhibited the onset of EPC senescence in culture. Resveratrol also significantly increased telomerase activity. Interestingly, quantitative real-time PCR analysis demonstrated that resveratrol dose-dependently increased the expression of the catalytic subunit, hTERT, an effect that was significantly inhibited by pharmacological phosphatidylinositol 3-kinase (PI3-K) blockers (wortmannin). The expression of hTERT is regulated by the PI3-K/Akt pathway; therefore, we examined the effect of resveratrol on Akt activity in EPCs. Immunoblotting analysis revealed that resveratrol led to dose-dependent phosphorylation and activation of Akt in EPCs.</p><p><b>CONCLUSION</b>Resveratrol delayed EPCs senescence in vitro, which may be dependent on telomerase activation.</p>