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Aim To explore the important role of HDAC5 in P-gp expression in rats in high-altitude low oxygen environment and its effect on phenytoin sodium pharmacokinetics. Methods Wistar rats were transported to Batang, Yushu, Qinghai, at an altitude of 4010 m, with 6 rats in each group, divided into 1 d and 3 d groups. Different groups were given phenytoin, phenytoin combined with hypericin, and phenytoin combined with verapamil. Plasma and liver tissues were collected at different time after taking the drug in the plateau area. The concentration of phenytoin sodium in plasma was determined by UFLC-MS method. Changes in protein expression were detected by Western blot. Results The results of UFLC-MS showed that the AUC
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<p><b>OBJECTIVE</b>To evaluate the clinical value of quantitative tissue velocity imaging (QTVI) in detection of regional wall movement abnormalities in patients with coronary artery disease (CAD).</p><p><b>METHODS</b>The segmental left ventricular wall motion velocity was measured in 45 normal subjects and 48 patients with CAD, and the parameters of QTVI were analyzed between the two groups.</p><p><b>RESULTS</b>Velocity decrement and wave form alterations were shown in abnormal segmental movements in the CAD group. There were obvious differences in the velocity between normal and abnormal segment.</p><p><b>CONCLUSION</b>QTVI is valuable in quantitative and sensitive evaluation of regional wall movement abnormalities for non-invasive diagnosis of CAD.</p>