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Journal of Southern Medical University ; (12): 947-951, 2016.
Artigo em Chinês | WPRIM | ID: wpr-286868

RESUMO

<p><b>OBJECTIVE</b>To prepare a novel strontium-containing calcium sulfate and assess its and biocompatibility.</p><p><b>METHODS</b>A novel strontium-containing α-calcium sulfate hemihydrate (Sr-caS) bone substitute as prepared with hydrothermal reaction and examined for X-ray diffraction (XRD), Fourier transform infrared (FTIR) and thermogravimetric differential scanning calorimetric (TG-DSC) patterns. The biocompatibility of the material was evaluated by in vitro cytotoxicity test in L-929 cells, hemolysis test of blood, and in vivo implantation test in SD rats.</p><p><b>RESULTS</b>The XRD spectra of the prepared Sr-CaS powder highlighted 3 strong characteristic peaks of α-CaSO4 at 14.63°, 25.72° and 29.80° with a strontium-specific peak at 24.78°. The FTIR patterns of Sr-CaS resembled those of CaS. TG-DSC results showed that the material contained a non-evaporable water content of 6.03%. In vitro cytotoxicity test in L-929 cells suggested that the material had a class 1 cytotoxicity, and the hemolysis rate of its aqueous extract was 4.3%. The material implanted in the muscular tissues of SD rats maintained a steady state in the surrounding tissues.</p><p><b>CONCLUSION</b>This strontium-containing calcium sulfate material we prepared shows an excellent biocompatibility for potential use as a novel artificial bone material.</p>


Assuntos
Animais , Camundongos , Ratos , Materiais Biocompatíveis , Química , Substitutos Ósseos , Química , Sulfato de Cálcio , Química , Linhagem Celular , Microscopia Eletrônica de Varredura , Próteses e Implantes , Ratos Sprague-Dawley , Espectroscopia de Infravermelho com Transformada de Fourier , Estrôncio , Química , Difração de Raios X
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