RESUMO
Hematopoietic stem cell transplantation is an important method for the treatment of hematological malignancies. The hematopoietic recovery after transplantation, graft-versus-host disease (GVHD) prevention and treatment are the key to affect transplant success. Umbilical cord mesenchymal stem cells (hUC-MSC) can improve the hematopoietic microenvironment, promote hematopoietic stem cell homing and hematopoietic recovery, support hematopoiesis. In aduition, the hUC-MSC have immune function for a variety of immune cells, can avoid and alleviate the host immune response, have a certain effect on the treatment of GVHD. This article reviews the research advances on umbilical cord mesenchymal stem cells in hematopoietic stem cell transplantation.
RESUMO
Objective To explore the effects of hepatocyte growth-promoting factor(pHGF) on renal function and cell apoptosis in kidney of rats with renal ischemia reperfusion injury(IRI).Methods Thirty-two male Sprague-Dawley rats were divided into 4 groups:sham-operated control group(groupⅠ),renal ischemia reperfusion control group(groupⅡ),one experimental group injecting pHGF(50 mg/kg,intraabdominal injection) before renal IRI(group Ⅲ),and another experimental group injecting pHGF(50 mg/kg,intraabdominal injection) after renal IRI(group Ⅳ).The animals with renal IRI exposed to 45 min bilateral renal pedicle clamping.All ischemia reperfusion rats in group Ⅰ and Ⅱ were intraabdomially injected equal volume of physiological saline(0.8 mL) at the time when the rats in experimental groups were administered 50 mg/kg pHGF.Twelve hours after IRI,samples for serum and the left renal tissue of each animal were taken.The serum sample was used to detect expression of serum creatinine(Scr),and the renal tissue sample for evaluation of apoptosis.Results Compared with the level of Scr in groupⅠ(22.775?6.508) ?mol/L,Scr was markedly higher in groupⅡ(120.850?22.237) ?mol/L(P0.05).Conclusions The laboratory investigation suggests that pHGF might be an effective pharmacological agent against renal IRI according to the findings of the evaluated parameters,and protective effect by pHGF against renal IRI might involved in the mechanisms decreasing tubular cells apoptosis.It is likely that pHGF is a potential therapentic agent in clinical renal IRI circumstances.