Pathologic changes of the cardiac conduction system in 12 patients with abnormal ECG / 中华心血管病杂志

<p><b>OBJECTIVE</b>To investigate the relationship between abnormal ECG and pathologic changes in the cardiac conduction system (CCS).</p><p><b>METHOD</b>Pathological changes of the CCS in 12 cases with abnormal ECG out of 16 pre-death ECG were observed.</p><p><b>RESULTS</b>(1) Among 7 cases of sudden cardiac death, ECG monitoring recorded bradyarrhythmia in 6 cases, tachyarrhythmia 6 cases, bradycardia-tachycardia syndrome 2 cases, conduction block 6 cases, atrial premature beats 6 cases, ventricular premature beats 6 cases, and ST-T changes 4 cases. (2) The histopathological findings in the CCS were noted in all cases. Of these 12 cases, three had signs of fatty infiltration, and/or fibrous 4 cases, three of amyloidosis, one of chronic inflammatory changes, two of acute inflammatory changes, two of developmental anomalies, two of hemorrhages and one of LAD stenosis. (3) Acute inflammation changes in the CCS corresponded to tachyarrhythmia and multiple ventricular premature beats, whereas chronic inflammation and degenerative changes in the CCS were often related to bradyarrhythmia, bradycardia-tachycardia syndrome and conduction block. (4) The CCS changes alone could lead to ST-T changes in ECG.</p><p><b>CONCLUSION</b>The pathological changes in the CCS are related to ECG changes, and attributed to the pathological bases of arrhythmia.</p>

Traumatic cerebral infarction: a histopathological study of 17 cases / 中华病理学杂志

<p><b>OBJECTIVE</b>To assess the morphologic changes in traumatic cerebral infarction and to discuss its mechanism.</p><p><b>METHODS</b>Specimens from seventeen cases of cerebral infarction were selected from 81 patients with severe brain injury, and subject to routine gross and histological examinations.</p><p><b>RESULTS</b>(1) The cerebral infarction in all cases was hemorrhagic in nature with a wedged or irregular shape upon gross inspection. The lesions were found in occipital gyrus (8 cases), occipital lobes (3 cases), basal nuclei (3 cases), cingulate gyrus (2 cases), and lateral occipitotemporal gyrus (1 case). Histologically, the lesions were located at the junction between the cortex and medulla, showing congestion, edema, hemorrhage, necrotic nerve tissue and blood vessels. In severe cases, the lesion extended into the entire cortex and subarachnoid spaces. (2) Swelling of the brain and cerebral hernia were found in all cases, 8 of which demonstrated that the posterior cerebral artery was compressed and stenotic within the space between the crus cerebri and uncus.</p><p><b>CONCLUSION</b>Brain tissue necrosis in traumatic cerebral infarction is the result of brain swelling and cerebral hernia formation, following congestion, bleeding and ischemia due to vasculature compression.</p>

Histochemical observation of changes of neurons and axons in injured brainstem / 法医学杂志

Brainstem of rats were stabbed with a needle and pathological changes of neurons and axons in brainstem were observed at different time after injury with Nissl's body staining, silver staining and modified trichrome staining. It was found that, by silver staining, the axons showed irregular swelling and disconnection at 1-3 h, marked swelling of the severe end at 6 h, retraction ball at 15 h and remarkable retraction ball at 24 h. By modified trichrome staining, the space between myelin sheaths and axons was widened at 3-6 h, and tortuous myelin sheaths adhered incompletely on axons, or even peeled off at 15 h to 24 h. Perinuclear lysis of Nissl's bodies at 24 h after injury could be seen by Nissl body staining. The results indicated that, the pathological changes in injured brainstem could be observed with histochemical staining, which might be used for timing brainstem injuries.

Diagnosis of non-typical myocarditis by applying immunohistochemical method of CD68 / 法医学杂志

OBJECTIVE@#To make a distinction between myocarditis and the reaction to some pathological state of myocardium.@*METHODS@#Myocardium of 26 cases with sudden cardiac death were stained and LM light microscopies with immunohistochemical method 10 cases with normal myocardium were contrasted.@*RESULTS@#A great deal of stained positive monocyte of immunohistochemistry emerged in the parasetions of myocarditis patients with various farms and stacking(> 15).@*CONCLUSION@#The stain of immunohistochemistry can be used as one of the indications for diagnosing non-typical myocarditis.