RESUMO
The disturbance of intestinal flora is closely related to the development of tumors. Studies showed that oral symbiotic strain Fusobacterium nucleatum was significantly enriched in a variety of tumors and promoted the disease progression, indicating poor prognosis of patients. Molecular mechanism studies found that Fusobacterium nucleatum could activate host cell cancer-related signaling pathways, trigger chronic inflammation, and suppress immune surveillance to enhance cancer cell proliferation, invasion, metastasis and anti-apoptosis. This article reviewed advances in research on relationship between Fusobacterium nucleatum and cancer.
RESUMO
Long non-coding RNAs (lncRNAs)are closely related to the tumorigenesis,proliferation, metastasis and clinical outcome,whihc play important roles in the process of drug resistance of many tumor cells.Recently,research indicates that many lncRNAs regulate drug resistance of tumor cells through a variety of signaling pathways both in vitro and in vivo.Furthermore,it is also found that after blocking the relevant tar-gets can reverse this chemoresistance.