Prospective study on the effect of BMI and waist circumference on diabetes of adults in Zhejiang province / 中华流行病学杂志

Objective To explore the effect of BMI and waist circumference on diabetes of adults.Methods After excluding participants with heart disease,stroke,cancer and diabetes at baseline study,53 916 people aged 30-79 in the China Kadoorie Biobank (CKB) study from Tongxiang city of Zhejiang province were recruited.Cox regression model was used to estimate the hazards ratios (HR) for the associations of baseline BMI and waist circumference with incident diabetes.Results Among 391 512 person-years of the follow-up program between 2004 and 2013 (median 7.26 years),a total of 944 men and 1 643 women were diagnosed as having diabetes.Compared to those with normal weight,after adjusting for known or potential factors,HR of both overweight and obesity in men for incident diabetes appeared as 2.72 (95％CI:2.47-2.99) and 6.27 (95％CI:5.33-7.36),respectively.The corresponding figures in women were 2.19 (95％CI:2.04-2.36)and 3.78 (95％CI:3.36-4.26).Compared to those with normal waist circumference,after adjusting for known or potential factors,HR of Ⅰ grade and Ⅱ grade in men for diabetes were 2.56 (95％ CI:2.22-2.95) and 4.66 (95％CI:4.14-5.24),respectively.The corresponding figures in women were 1.99 (95％CI:1.80-2.21) and 3.16 (95％CI:2.90-3.44),respectively.Conclusions Overweight,obesity and central obesity were all associated with the increased incident of diabetes.Strategies on diabetes prevention should include not only losing weight,but reducing waist circumference as well.

Association between tea drinking and stroke in adults in Zhejiang province: a prospective study / 中华流行病学杂志

Objective To prospectively explore the association between tea drinking and incidence of stroke of adults of Zhejiang province.Methods After excluding participants with heart disease,stroke,cancer and diabetes at baseline study,53 916 participants aged 30-79 years in the China Kadoorie Biobank (CKB) study from Tongxiang were included for final analysis.Cox regression model was used to estimate the hazard ratio (HR) for the association of tea drinking with incident stroke.Results The main type of drinking tea was black tea (79.78％),followed by green tea (20.08％).Of the 53 916 participants,the proportion of participants who drank tea at least once per week was 31.27％.The corresponding proportions for men and women were 60.24％ and 10.30％,respectively.Among 391 512 person-years of the follow-up program (median 7.26 years),a total of 1 487 men and 1 769 women were diagnosed with stroke.After adjusting for socio-demographic status,lifestyle,BMI,waist circumference,and systolic blood pressure,HR for incident stroke decreased with the increase of daily average tea consumption amount (P=0.000 6).Compared with participants who did not drink tea weekly,the HRs for incident stroke in those consuming tea 0.1-,3.0-and ≥5.0 g/d were 0.93 (95％ CI:0.85-1.00),0.88 (95％ CI:0.77-0.99) and 0.79 (95％ CI:0.69-0.89),respectively.The HRs for incident stroke in smokers and non-smokers who consumed tea ≥5.0 g/d were 0.71 (95％CI:0.59-0.86) and 0.97 (95％CI:0.77-1.21),respectively,compared with current smokers and non-smokers who did not drink tea weekly (P=0.040 0).The corresponding HRs for alcohol drinkers and non-drinkers were 0.96 (95％CI:0.76-1.22) and 0.70 (95％CI:0.58-0.84),respectively (P=0.040 0).The corresponding HRs for central obese persons and non-central obese persons were 0.60 (95％ C1:0.44-0.81) and 0.86 (95％ CI:0.73-1.01),respectively (P=0.040 0).Conclusion Tea drinking had an effect on reducing the possibility of incident stroke,especially among those who were current smokers,non-alcohol drinkers and central obese.

Prospective study on the effect of BMI and waist circumference on diabetes of adults in Zhejiang province / 中华流行病学杂志

Objective: To explore the effect of BMI and waist circumference on diabetes of adults. Methods: After excluding participants with heart disease, stroke, cancer and diabetes at baseline study, 53 916 people aged 30-79 in the China Kadoorie Biobank (CKB) study from Tongxiang city of Zhejiang province were recruited. Cox regression model was used to estimate the hazards ratios (HR) for the associations of baseline BMI and waist circumference with incident diabetes. Results: Among 391 512 person-years of the follow-up program between 2004 and 2013 (median 7.26 years), a total of 944 men and 1 643 women were diagnosed as having diabetes. Compared to those with normal weight, after adjusting for known or potential factors, HR of both overweight and obesity in men for incident diabetes appeared as 2.72 (95%CI: 2.47-2.99) and 6.27 (95%CI: 5.33-7.36), respectively. The corresponding figures in women were 2.19 (95%CI: 2.04-2.36) and 3.78 (95%CI: 3.36-4.26). Compared to those with normal waist circumference, after adjusting for known or potential factors, HR of Ⅰgrade andⅡgrade in men for diabetes were 2.56 (95%CI: 2.22-2.95) and 4.66 (95%CI: 4.14-5.24), respectively. The corresponding figures in women were 1.99 (95%CI: 1.80-2.21) and 3.16 (95%CI: 2.90-3.44), respectively. Conclusions: Overweight, obesity and central obesity were all associated with the increased incident of diabetes. Strategies on diabetes prevention should include not only losing weight, but reducing waist circumference as well.

Association between tea drinking and stroke in adults in Zhejiang province: a prospective study / 中华流行病学杂志

Objective: To prospectively explore the association between tea drinking and incidence of stroke of adults of Zhejiang province. Methods: After excluding participants with heart disease, stroke, cancer and diabetes at baseline study, 53 916 participants aged 30-79 years in the China Kadoorie Biobank (CKB) study from Tongxiang were included for final analysis. Cox regression model was used to estimate the hazard ratio (HR) for the association of tea drinking with incident stroke. Results: The main type of drinking tea was black tea (79.78%), followed by green tea (20.08%). Of the 53 916 participants, the proportion of participants who drank tea at least once per week was 31.27%. The corresponding proportions for men and women were 60.24% and 10.30%, respectively. Among 391 512 person-years of the follow-up program (median 7.26 years), a total of 1 487 men and 1 769 women were diagnosed with stroke. After adjusting for socio-demographic status, lifestyle, BMI, waist circumference, and systolic blood pressure, HR for incident stroke decreased with the increase of daily average tea consumption amount (P=0.000 6). Compared with participants who did not drink tea weekly, the HRs for incident stroke in those consuming tea 0.1-, 3.0- and ≥5.0 g/d were 0.93 (95%CI: 0.85-1.00), 0.88 (95%CI: 0.77-0.99) and 0.79 (95%CI: 0.69-0.89), respectively. The HRs for incident stroke in smokers and non-smokers who consumed tea ≥5.0 g/d were 0.71 (95%CI: 0.59-0.86) and 0.97 (95%CI: 0.77-1.21), respectively, compared with current smokers and non-smokers who did not drink tea weekly (P=0.040 0). The corresponding HRs for alcohol drinkers and non-drinkers were 0.96 (95%CI: 0.76-1.22) and 0.70 (95%CI: 0.58-0.84), respectively (P=0.040 0). The corresponding HRs for central obese persons and non-central obese persons were 0.60 (95%CI: 0.44-0.81) and 0.86 (95%CI: 0.73-1.01), respectively (P=0.040 0). Conclusion: Tea drinking had an effect on reducing the possibility of incident stroke, especially among those who were current smokers, non-alcohol drinkers and central obese.

Association between sleep duration and stroke in adults / 中华流行病学杂志

<p><b>OBJECTIVE</b>To explore the association between sleep duration and stroke in adults.</p><p><b>METHODS</b>Baseline data of 57 704 subjects who were aged 30-79 years and enrolled into China Kadoorie Biobank (CKB) study from Tongxiang county, Zhejiang province were analyzed. Multiple logistic regression analysis was conducted to investigate the putative association between sleep duration and stroke after adjusting for potential confounders.</p><p><b>RESULTS</b>The mean age of the subjects was (53.15 ± 10.20) years in males and (51.72 ± .69) years in females, respectively. There were 14.43% of males and 15.30% of females reporting sleep durations ≤ 6 hours per day and 5.39% of males and 5.95% of females reporting long duration of sleep (≥ 10 hours per day). The prevalence of stroke was 0.92% in males compared with 0.44% in females. The prevalence of stroke showed a U-shaped distribution with sleep duration. Compared with 7 hours sleep duration per day, long sleep duration (≥ 10 hours per day) was associated with stroke. The odds ratios (OR) were 2.11 (95%CI: 1.32-3.37) for males and 2.13 (95%CI: 1.24-3.65) for females after adjusting for age, socioeconomic status, health behaviors and health status. No statistical significant association was found between short sleep duration and stroke. Meanwhile, frequent sleep snoring was found to be associated with stroke in females (OR=1.63, 95% CI: 1.11-2.40).</p><p><b>CONCLUSION</b>Longer sleep duration was found to be associated with higher risk of stroke in both males and females. Frequent sleep snoring would increase the risk of stroke in females.</p>

Evaluation of (99m)Tc-MIBI myocardial perfusion imaging with intravenous infusion of adenosine triphosphate in diagnosis of coronary artery disease / 中华医学杂志(英文版)

<p><b>OBJECTIVE</b>To evaluate the feasibility, safety and diagnostic accuracy of pharmacologic stress of (99m)Technetium-MIBI single-photon emission computed tomography (SPECT) with intravenous adenosine triphosphate (ATP) in patients with suspected coronary artery disease.</p><p><b>METHODS</b>The study group included 263 patients who were suspected of having coronary artery disease. All patients underwent (99m)Tc-MIBI myocardial perfusion imaging with ATP infusion (0.16 mg/kg body weight per min for 5 min). 20 mCi of (99m)Tc-MIBI were injected 3 minutes after the start of ATP infusion. Myocardial SPECT images were obtained 60 minutes later. Then, two days later, 20 mCi of (99m)Tc-MIBI were administered at rest and myocardial SPECT was repeated. 51 patients also underwent coronary angiography within two weeks for evaluation of sensitivity and specificity of ATP-myocardial perfusion imaging in detection of coronary artery disease. The occurrence of cardiac and non-cardiac adverse effects was carefully monitored during and after intravenous ATP infusion.</p><p><b>RESULTS</b>The ATP infusion protocol was completed in all patients. Although 59% of the patients had various kinds of adverse effects, most of them were mild. No patient required aminophyline. The most severe adverse effect was second degree type II atria-ventricular block (4/263), but all events were transient. The sensitivity and specificity of ATP-myocardial perfusion imaging were 97% and 82%, respectively.</p><p><b>CONCLUSIONS</b>It is shown that (99m)Technetium-MIBI SPECT with intravenous ATP is a safe and feasible technique for detecting coronary artery disease in patients unable to perform the exercise test.</p>