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Objective To explore the current status and predictive factors of frailty among community-dwelling old adults.Methods A total of 1 012 community-dwelling older adults aged 65 years and above in Sichuan Province were enrolled and investigated by self-made general condition scale,Tilburg Frailty Indicator (TFI),Short Physical Performance Battery (SPPB),10-item Connor-Davidson Resilience Scale (CD-RISC-10),Mini-Mental State Examination (MMSE) and Geriatric Depression Scale Short-form (GDS-15).Results (1) The prevalence of frailty was 30.73％.(2) There were significant differences in the frailty scores of community-dwelling older adults in terms of gender,education,marital status,living condition,spouse support,children support,family economic conditions,self-perceived health status,number of chronic diseases,body mass index,number of falls in the past year,exercise state and sleep time at night(all P＜0.05).(3) The frailty (3.72±2.88) was significantly positively correlated with depression (2.69± 2.58;r=0.58,P＜0.01),and negatively correlated with the scores of balance ability(3.28± 1.01),walking speed (2.92± 1.05),chair rise test (2.92± 1.27),strength of resilience (13.99±3.57) and MMSE (23.71 ±5.55) (r=-0.33-0.43,P＜0.01).(4) Depression (β=0.416,P＜0.001),the number of chronic diseases (β=0.219,P＜0.001),balance ability (β=-0.166,P＜0.001),spousal support (β=-0.089,P＜0.01),strength of resilience(β =-0.097,P＜0.01),family economic status(β=0.093,P＜0.01) and gender(β=0.082,P＜0.01) significantly influenced frailty,with a combined explanation variance of 45.9％.Conclusions The rate of frailty of community-dwelling old adults is high,which is influenced by physiological,psychological and social factors.Therefore,it is necessary to adopt a comprehensive model of multi-disciplinary cooperation to carry out frailty intervention in community.
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Objective@#To explore the current status and predictive factors of frailty among community-dwelling old adults.@*Methods@#A total of 1 012 community-dwelling older adults aged 65 years and above in Sichuan Province were enrolled and investigated by self-made general condition scale, Tilburg Frailty Indicator (TFI), Short Physical Performance Battery(SPPB), 10-item Connor-Davidson Resilience Scale(CD-RISC-10), Mini-Mental State Examination(MMSE) and Geriatric Depression Scale Short-form(GDS-15).@*Results@#(1) The prevalence of frailty was 30.73%.(2) There were significant differences in the frailty scores of community-dwelling older adults in terms of gender, education, marital status, living condition, spouse support, children support, family economic conditions, self-perceived health status, number of chronic diseases, body mass index, number of falls in the past year, exercise state and sleep time at night(all P<0.05). (3) The frailty (3.72±2.88) was significantly positively correlated with depression (2.69±2.58; r=0.58, P<0.01), and negatively correlated with the scores of balance ability(3.28±1.01), walking speed(2.92±1.05), chair rise test(2.92±1.27), strength of resilience(13.99±3.57) and MMSE(23.71±5.55) (r=-0.33-0.43, P<0.01). (4) Depression (β=0.416, P<0.001), the number of chronic diseases(β=0.219, P<0.001), balance ability(β=-0.166, P<0.001), spousal support(β=-0.089, P<0.01), strength of resilience(β =-0.097, P<0.01), family economic status(β=0.093, P<0.01) and gender(β=0.082, P<0.01) significantly influenced frailty, with a combined explanation variance of 45.9%.@*Conclusions@#The rate of frailty of community-dwelling old adults is high, which is influenced by physiological, psychological and social factors.Therefore, it is necessary to adopt a comprehensive model of multi-disciplinary cooperation to carry out frailty intervention in community.
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<p><b>OBJECTIVE</b>To explore the genotoxicity of bass wood dust.</p><p><b>METHODS</b>Micronucleus frequency in peripheral lymphocytes of workers exposed to bass wood dust in a match factory were examined, solution of bass wood dust emmersion was prepared and the effect on micronucleus frequency in poly-dyeing red blood cell of mice's sternum marrow was also detected. Single cell gel electrophoresis assay was used to detect DNA damage in liver cell, the level of oxygen free radical, lipid peroxidation(MDA) in the liver and the activity of superoxide dismutase(SOD) in red blood cells were also studied.</p><p><b>RESULTS</b>The positive frequency of micronucleus in bass wood-exposed workers with different length of service (0-, 5-, > or = 10 a) were 50.0%, 51.9%, 50.0% respectively, significantly higher (P < 0.01) than that of the control group(4.5%). A dose-effect relationship could also be found in the mice's micronucleus frequency study(r = 0.78, P < 0.01). The activities of SOD[(10.98 +/- 5.74), (15.70 +/- 7.54), (29.63 +/- 14.97) microgram/g Hb] were significantly lower than that of control group[(35.80 +/- 12.92) microgram/g Hb], and the level of MDA[(4.93 +/- 0.90), (4.61 +/- 1.06), (4.33 +/- 0.69) mmol/g liver] were significantly higher than that of the control group[(2.51 +/- 0.34) mmol/g liver]. Single cell gel electrophoresis study showed DNA strand breaks increased with the dose increase and the level of oxygen free radical also increased with the dose increase.</p><p><b>CONCLUSION</b>Bass wood dust may have certain degree of genotoxicity.</p>