RESUMO
With the development of medical nanotechnology, scientists have found that nanoparticle drug delivery system can improve the accumulation of anti-tumor drugs inside the tumor and reduce the damage to normal tissues, so as to increase the treatment effect while decrease its side effect. In recent years, the nanoparticle drug delivery system has been gradually developing towards intellectualization, and various smart probes which are stimuli-responsive and sensitive to microenvironment of tumor have been designed. Those probes can be divided into two categories: internal (including pH, enzyme, and redox) and external (including light, temperature, ultrasound, and magnetic field) environment-responsive probes. In this paper, the latest research progress in the two kinds of environment-responsive smart probes in the field of tumor therapy is reviewed, and the further research direction is also prospected.