Clinical significance of serum carbohydrate antigen 125 in acute exacerbation of chronic obstructive pulmonary disease / 南方医科大学学报

<p><b>OBJECTIVE</b>To study the serum level of carbohydrate antigen 125 (CA125) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its relation with pulmonary hypertension.</p><p><b>METHODS</b>Forty-six patients with AECOPD complicated by pulmonary hypertension, 46 with AECOPD and 38 healthy control subjects were examined for their clinical data, pulmonary function, echocardiographic findings, and serum levels of lung tumor markers and brain natriuretic peptide (BNP).</p><p><b>RESULTS</b>Compared with the healthy control group, COPD patients with or without pulmonary hypertension showed significantly decreased pulmonary function (P<0.05), especially in those with AECOPD and concurrent pulmonary hypertension (P<0.05). Serum CA125 level was obviously higher in AECOPD group than in the healthy control group, and further increased in AECOPD patients with pulmonary hypertension (P<0.05). The levels of lung tumor markers (CEA, NSE, CYFRA and PROGRP) were similar among the 3 groups (P>0.05). The serum level of BNP in patients with AECOPD and concurrent pulmonary hypertension was significantly higher than that in patients with AECOPD (P<0.05). Pearson linear correlation analysis showed that serum CA125 was positively correlated with pulmonary artery systolic pressure and BNP in AECOPD patients with pulmonary hypertension (P<0.01).</p><p><b>CONCLUSION</b>Serum CA125 may serve as a serological index to identify AECOPD patients with pulmonary hypertension.</p>

Advances in research on chemical constituents and pharmacological activities of Celtis sinensis / 中国药学杂志

To provide scientific and theoretical basis for the further study and reference for the development and efficient use of the medicinal plants, the extraction and separation technology of Celtis sinensis and its main chemical components and pharmacological effects were summarized. Literatures were reviewed, and the key information was classified and summarized. A large number of flavonoids, triterpenoids, phenols, anthraquinones and amides have been isolated from the plants. Extract of Celtis shows diversed pharmacological activities, such as antioxidant, anti-inflammatory, antibacterial, anti-tumor and so on. Further studies should be carried out on Celtis sinensis, which is abundant in our country and has high medicinal value and broad application prospect, for its better development and utilization.