RESUMO
@#【Objective】To determine the effect of ovarian stimulation or in vitro maturation for fertility preservation in female cancer patients. 【Methods】 A retrospective study was conducted in 27 females who underwent fertility preservation procedures in our center.【Results】Female patients were included in this study with an average age of 27.1. Patients spent on average for 6.8 d to retrieve oocytes since their attendance day. Total amount of Gn was on average 910 U per patient and for patients with breast cancer，the average estrogen level on trigger day reached 360 pg/mL. The maturation rate of oocytes from ovarian stimulation cycles was 82.6% ，which of that in emergency in- vitro maturation cycles was 38.1%.【Conclusion】The development capability of oocytes from cancer patients are comparable with those of other infertility patients. Peak estradiol levels were controlled by the administration of letrozole. In vitro maturation of oocytes performed at random time of the menstrual cycle may result in a lower maturation rate ，which is associated with the time limit of the follow- up cancer treatment. In conclusion，clinicians should consider a more holistic approach for female cancer patients，which focuses not only on the characteristic of the primary cancer but also on the phase of the menstrual cycle at their attendance day.
RESUMO
Objective To study the clinical value of growth differentiation factor-15 (GDF-15) in judgment of the degree of myocardial injury in children with critical illness.Methods Fifty cases of children [pediatric critical illness score (PCIS) ≤ 80] without primary cardiac disease in Pediatric Intensive Care Unit (PICU) of Changzhou Children's Hospital Affiliated to Nantong University were selected after hospitalization,and 20 healthy children were taken as normal control group (n =20).The level of GDF-15 in peripheral blood serum were detected by enzyme-linked immunosorbent assay and biochemical indicators like troponin I (cTnI),creatine kinase isoenzyme (CK-MB) and so on were recorded.Fifty cases of critically ill children were divided into myocardial injury group (n =23),and without myocardial injury group(n =27),according to the myocardial injury standard which was cTnI ＞ 0.2 μg/L.The relationship between the level of GDF-15 and myocardial injury in critically ill children was observed,and the correlation analysis of GDF-15 and cTnI was performed.Results 1.The rate of the myocardial injury in critically ill children was 46％ (23/50 cases).2.Compared with the without myocardial injury group [25.93％ (7/27 cases)] and the normal control group [5.00％ (1/20 cases)],GDF-15 positive rate in myocardial injury group [60.87％ (14/23 cases)] was significantly higher,and there were significant differences (P =0.027,0.000) ; there was no significant difference between the without myocardial injury group and the normal control group (P =0.056).3.The levels of GDF-15 had significant difference between myocardial injury group and the without myocardial injury group (P =0.000).4.GDF-15 was positively correlated with cTnI (r =0.9704,P ＜ 0.05).Conclusions The level of GDF-15 with myocardial injury in critically ill children is higher than that of without myocardial injury children.GDF-15 and cTnI have an important value in judging the degree of myocardial injury of critically ill children.