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Acute severe cholangitis is a serious disease with fast development and high mortality. The therapeutic options are stills limited. Once diagnosed, the key step of treatment is to timely reduce the high pressure of bile duct caused by biliary obstruction, and to block bacteria and toxins from entering the blood, which might trigger inflammation " cascade reaction" . The policy of " relieve obstruction, remove lesions, and bile duct drainage" raised by academician Huang Zhiqiang, is still the criterion for acute cholangitis treatment. Active biliary drainage, early continuous renal replacement therapy, and simultaneous antibacterial therapy and multi-organ function support can significantly improve the disease outcome and reduce mortality.
RESUMO
Objective To investigate the relationship between electrophysiological and morphological properties of neurons in visual cortex of developing rat, speculate the coincided degree between electrophysiological and morphological change and realize the mechanism of normal visual development. Methods Whole cell patch-clamp recording and intracellular staining were used to acquire cellular microelectrode recording in visual cortex from Sprague-Dawley rats (4~28 days old). The histological process was made. Results The differences of electrical feature between pyramidal cells and non-pyramidal cells were significant. The morphological maturity degree is different in developing visual cortex. Conclusion The different function of pyramidal and non- pyramidal cells in local integrition is reflected by their electrical feature in the process of visual development. In critical period of visual development, the coincision degree of the electrophysiological and morphological change in visual cortex is larger than that in the subcortex constructure.
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Four hours after the spinal cord of rats was injured,the contents of malondi-aldehyde(MDA)and free fatty acid(FFA)were significantly increased,the activity of xan-thine oxidase(XOD)elevated,the activity of superoxide dismutase(SOD)reduced,and the calcium content significantly increased in the tissues of the injured cord.These facts suggest that there is the generation of calcium-mediated free radicals and lipid peroxidation in the membrane.Intravenous injection of saponins of Panax notoginseng(PNS)in the dosage of 30,90,and 270mg/kg could all inhibit the production of MDA; 270mg/kg could inhibit the release of FFA and the activity of XOD;90mg/kg could significantly decrease the calcium content.These findings indicate that the inhibition of PNS on the calcium influx might be one of the mechanisms of anti-lipid peroxidation in spinal cord injury in rats.
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The thoracic aorlae of 39 goats and the inferior venae cavae of 9 goats were anastomosed experimentally with the Large Blood Vessel Anastomat. The pathological changes of these vessels were observed dynamically within one year after the operation. It was found that the Large Blood Vessel Anastomat was rather effective. The vessels anastomosed with this instrument showed a better result than those anastomosed with manual suture.