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Purpose:To investigate the susceptible factors and treatment against cross infection in hospital of cancer patients.Methods:174 cases of cross infection in hospital of cancer patients from 1997 to 1999 were analyzed for infective site, infective agent and infectious bacteria. Results:174 cases of cross infection in hospital of cancer patients were found, which was 10.45% of the in paitents of the same period. The majority (108/174) had infection of tissues and organs within irradiation fields after radiotherapy. Respiratory tract infection rate was 76.43%. 16 cases (40.0%) were found to have secondary infection of digestive canal after chemotherapy in the 40 cases of infection of digestive canal. Bone marrow deression or chronic failure and long term decubitus were also causes of infection. In addition, mycotic infection was 43.42% (33/76) in bacteriological tests with bad prognosis.Conclusions:Cross infection in the hospital occurs that patients enfeebled by radiotherapy, chemotherapy, chronic bone marrow failure and long term decubitus. Attention should be paid to the possibility of mycotic cross infection in hospitals, as the prognosis could be quite serious. As soon as the diagnosis is confirmed, early and full dose treatment by anti mycotic drugs should be given.
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Objective To compare the efficacy between bronchial artery infusion (BAI) chemotherapy plus radiation therapy and systemic chemotherapy plus radiation for locally advanced non-small cell lung cancer (NSCLC). Methods One hundred and twenty-one patients with stage III NSCLC were randomized into treatment group(58 cases) and control group (63 cases). In the treatment group, all patients were administered with BAI for 2-3 sessions, followed by irradiation 4-7 days after BAI. In the control group, altogether 4-6 cycles of standard systemic chemotherapy were given. Radiation was delivered alternately between the cycles of chemotherapy. Results The short-term, long-term survival, median response duration and median survival time were similar between the two groups, except patients with stage Ⅲb who had a higher distant metastasis rate in the treatment group. The major side effects of chemotherapy and radiotherapy were hematological, gastrointestinal toxicities, pneumonitis, mediastinitis, and esophagitis, respectively. The side effects were milder, better tolerated and did not influence the regimen schedule in the treatment group, as compared with the control group. Seven patients withdrew from the control group, and in 28 patients, the scheduled chemotherapy and radiation was delayed or canceled. Conclusions Bronchial artery infusion plus radiation is more advantageous over systemic chemotherapy plus radiation in less toxicities, better compliance, shorter treatment courses and more cost-effectiveness.